Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Leila Lujan-Barroso, Carlos Alberto González, Nadia Slimani, Mireia Obón-Santacana, Pietro Ferrari, Heinz Freisling, Kim Overvad, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Antoine Racine, Verena Katzke, Tilman Kühn, Anne Tjønneland, Anja Olsen, J. Ramón Quirós, Emilio Sánchez-Cantalejo, Pilar Amiano, Carmen Navarro, Aurelio Barricarte, Kay Tee KhawNick Wareham, Ruth C. Travis, Antonia Trichopoulou, Christina Bamia, Vassiliki Benetou, Calogero Saieva, Sara Grioni, Rosario Tumino, Paolo Vineis, Amalia Mattiello, H. Bas Bueno-De-Mesquita, Peter D. Siersema, Mattijs E. Numans, Petra H. Peeters, Ulrika Ericson, Elisabet Wirfält, Malin Sund, Mattias Johansson, Elisabete Weiderpass, Guri Skeie, Elio Riboli, Heiner Boeing, Eric J. Duell

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day. Results: After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HR Q2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61), but not in the fourth quartile, and there was no evidence for a linear dose-response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake. Conclusions: In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalCancer Causes and Control
Volume25
Issue number5
DOIs
Publication statusPublished - 2014

Fingerprint

Acrylamide
Esophageal Neoplasms
Adenocarcinoma
Neoplasms
Confidence Intervals
Proportional Hazards Models
Biomarkers
Esophageal Squamous Cell Carcinoma

Keywords

  • Acrylamide intake
  • Cohort
  • Esophageal adenocarcinoma
  • Esophageal cancer
  • Esophageal squamous cell carcinoma
  • Nutrition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lujan-Barroso, L., González, C. A., Slimani, N., Obón-Santacana, M., Ferrari, P., Freisling, H., ... Duell, E. J. (2014). Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Cancer Causes and Control, 25(5), 639-646. https://doi.org/10.1007/s10552-014-0359-5

Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. / Lujan-Barroso, Leila; González, Carlos Alberto; Slimani, Nadia; Obón-Santacana, Mireia; Ferrari, Pietro; Freisling, Heinz; Overvad, Kim; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Racine, Antoine; Katzke, Verena; Kühn, Tilman; Tjønneland, Anne; Olsen, Anja; Quirós, J. Ramón; Sánchez-Cantalejo, Emilio; Amiano, Pilar; Navarro, Carmen; Barricarte, Aurelio; Khaw, Kay Tee; Wareham, Nick; Travis, Ruth C.; Trichopoulou, Antonia; Bamia, Christina; Benetou, Vassiliki; Saieva, Calogero; Grioni, Sara; Tumino, Rosario; Vineis, Paolo; Mattiello, Amalia; Bueno-De-Mesquita, H. Bas; Siersema, Peter D.; Numans, Mattijs E.; Peeters, Petra H.; Ericson, Ulrika; Wirfält, Elisabet; Sund, Malin; Johansson, Mattias; Weiderpass, Elisabete; Skeie, Guri; Riboli, Elio; Boeing, Heiner; Duell, Eric J.

In: Cancer Causes and Control, Vol. 25, No. 5, 2014, p. 639-646.

Research output: Contribution to journalArticle

Lujan-Barroso, L, González, CA, Slimani, N, Obón-Santacana, M, Ferrari, P, Freisling, H, Overvad, K, Clavel-Chapelon, F, Boutron-Ruault, MC, Racine, A, Katzke, V, Kühn, T, Tjønneland, A, Olsen, A, Quirós, JR, Sánchez-Cantalejo, E, Amiano, P, Navarro, C, Barricarte, A, Khaw, KT, Wareham, N, Travis, RC, Trichopoulou, A, Bamia, C, Benetou, V, Saieva, C, Grioni, S, Tumino, R, Vineis, P, Mattiello, A, Bueno-De-Mesquita, HB, Siersema, PD, Numans, ME, Peeters, PH, Ericson, U, Wirfält, E, Sund, M, Johansson, M, Weiderpass, E, Skeie, G, Riboli, E, Boeing, H & Duell, EJ 2014, 'Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort', Cancer Causes and Control, vol. 25, no. 5, pp. 639-646. https://doi.org/10.1007/s10552-014-0359-5
Lujan-Barroso, Leila ; González, Carlos Alberto ; Slimani, Nadia ; Obón-Santacana, Mireia ; Ferrari, Pietro ; Freisling, Heinz ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Racine, Antoine ; Katzke, Verena ; Kühn, Tilman ; Tjønneland, Anne ; Olsen, Anja ; Quirós, J. Ramón ; Sánchez-Cantalejo, Emilio ; Amiano, Pilar ; Navarro, Carmen ; Barricarte, Aurelio ; Khaw, Kay Tee ; Wareham, Nick ; Travis, Ruth C. ; Trichopoulou, Antonia ; Bamia, Christina ; Benetou, Vassiliki ; Saieva, Calogero ; Grioni, Sara ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-De-Mesquita, H. Bas ; Siersema, Peter D. ; Numans, Mattijs E. ; Peeters, Petra H. ; Ericson, Ulrika ; Wirfält, Elisabet ; Sund, Malin ; Johansson, Mattias ; Weiderpass, Elisabete ; Skeie, Guri ; Riboli, Elio ; Boeing, Heiner ; Duell, Eric J. / Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. In: Cancer Causes and Control. 2014 ; Vol. 25, No. 5. pp. 639-646.
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T1 - Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

AU - Lujan-Barroso, Leila

AU - González, Carlos Alberto

AU - Slimani, Nadia

AU - Obón-Santacana, Mireia

AU - Ferrari, Pietro

AU - Freisling, Heinz

AU - Overvad, Kim

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Racine, Antoine

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Quirós, J. Ramón

AU - Sánchez-Cantalejo, Emilio

AU - Amiano, Pilar

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Benetou, Vassiliki

AU - Saieva, Calogero

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Mattiello, Amalia

AU - Bueno-De-Mesquita, H. Bas

AU - Siersema, Peter D.

AU - Numans, Mattijs E.

AU - Peeters, Petra H.

AU - Ericson, Ulrika

AU - Wirfält, Elisabet

AU - Sund, Malin

AU - Johansson, Mattias

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Riboli, Elio

AU - Boeing, Heiner

AU - Duell, Eric J.

PY - 2014

Y1 - 2014

N2 - Purpose: The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day. Results: After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HR Q2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61), but not in the fourth quartile, and there was no evidence for a linear dose-response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake. Conclusions: In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.

AB - Purpose: The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day. Results: After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HR Q2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61), but not in the fourth quartile, and there was no evidence for a linear dose-response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake. Conclusions: In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.

KW - Acrylamide intake

KW - Cohort

KW - Esophageal adenocarcinoma

KW - Esophageal cancer

KW - Esophageal squamous cell carcinoma

KW - Nutrition

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