Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Raul Zamora-Ros, Valerie Cayssials, Mazda Jenab, Joseph A Rothwell, Veronika Fedirko, Krasimira Aleksandrova, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Marie-Christine Boutron-Ruault, Franck Carbonnel, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elissavet Valanou, Effie Vasilopoulou, Giovanna Masala, Valeria PalaSalvatore Panico, Rosario Tumino, Fulvio Ricceri, Elisabete Weiderpass, Marko Lukic, Torkjel M Sandanger, Cristina Lasheras, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Bodil Ohlsson, Lena Maria Nilsson, Martin Rutegård, Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Kathryn Bradbury, Heinz Freisling, Isabelle Romieu, Amanda J Cross, Paolo Vineis, Augustin Scalbert

Research output: Contribution to journalArticle

Abstract

Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.

Original languageEnglish
JournalEuropean Journal of Epidemiology
DOIs
Publication statusE-pub ahead of print - May 15 2018

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Polyphenols
Colorectal Neoplasms
Rectal Neoplasms
Colonic Neoplasms
Neoplasms
Rectum
Colon
Coffee
Phenol
Proportional Hazards Models
Flavonoids
Databases

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Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. / Zamora-Ros, Raul; Cayssials, Valerie; Jenab, Mazda; Rothwell, Joseph A; Fedirko, Veronika; Aleksandrova, Krasimira; Tjønneland, Anne; Kyrø, Cecilie; Overvad, Kim; Boutron-Ruault, Marie-Christine; Carbonnel, Franck; Mahamat-Saleh, Yahya; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; Valanou, Elissavet; Vasilopoulou, Effie; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Weiderpass, Elisabete; Lukic, Marko; Sandanger, Torkjel M; Lasheras, Cristina; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Navarro, Carmen; Ardanaz, Eva; Sonestedt, Emily; Ohlsson, Bodil; Nilsson, Lena Maria; Rutegård, Martin; Bueno-de-Mesquita, Bas; Peeters, Petra H; Khaw, Kay-Thee; Wareham, Nicholas J; Bradbury, Kathryn; Freisling, Heinz; Romieu, Isabelle; Cross, Amanda J; Vineis, Paolo; Scalbert, Augustin.

In: European Journal of Epidemiology, 15.05.2018.

Research output: Contribution to journalArticle

Zamora-Ros, R, Cayssials, V, Jenab, M, Rothwell, JA, Fedirko, V, Aleksandrova, K, Tjønneland, A, Kyrø, C, Overvad, K, Boutron-Ruault, M-C, Carbonnel, F, Mahamat-Saleh, Y, Kaaks, R, Kühn, T, Boeing, H, Trichopoulou, A, Valanou, E, Vasilopoulou, E, Masala, G, Pala, V, Panico, S, Tumino, R, Ricceri, F, Weiderpass, E, Lukic, M, Sandanger, TM, Lasheras, C, Agudo, A, Sánchez, M-J, Amiano, P, Navarro, C, Ardanaz, E, Sonestedt, E, Ohlsson, B, Nilsson, LM, Rutegård, M, Bueno-de-Mesquita, B, Peeters, PH, Khaw, K-T, Wareham, NJ, Bradbury, K, Freisling, H, Romieu, I, Cross, AJ, Vineis, P & Scalbert, A 2018, 'Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort', European Journal of Epidemiology. https://doi.org/10.1007/s10654-018-0408-6
Zamora-Ros, Raul ; Cayssials, Valerie ; Jenab, Mazda ; Rothwell, Joseph A ; Fedirko, Veronika ; Aleksandrova, Krasimira ; Tjønneland, Anne ; Kyrø, Cecilie ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Carbonnel, Franck ; Mahamat-Saleh, Yahya ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; Valanou, Elissavet ; Vasilopoulou, Effie ; Masala, Giovanna ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Ricceri, Fulvio ; Weiderpass, Elisabete ; Lukic, Marko ; Sandanger, Torkjel M ; Lasheras, Cristina ; Agudo, Antonio ; Sánchez, Maria-Jose ; Amiano, Pilar ; Navarro, Carmen ; Ardanaz, Eva ; Sonestedt, Emily ; Ohlsson, Bodil ; Nilsson, Lena Maria ; Rutegård, Martin ; Bueno-de-Mesquita, Bas ; Peeters, Petra H ; Khaw, Kay-Thee ; Wareham, Nicholas J ; Bradbury, Kathryn ; Freisling, Heinz ; Romieu, Isabelle ; Cross, Amanda J ; Vineis, Paolo ; Scalbert, Augustin. / Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In: European Journal of Epidemiology. 2018.
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title = "Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort",
abstract = "Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95{\%} CI 0.99-1.14) or in men (HRlog2 = 0.97, 95{\%} CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95{\%} CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95{\%} CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.",
author = "Raul Zamora-Ros and Valerie Cayssials and Mazda Jenab and Rothwell, {Joseph A} and Veronika Fedirko and Krasimira Aleksandrova and Anne Tj{\o}nneland and Cecilie Kyr{\o} and Kim Overvad and Marie-Christine Boutron-Ruault and Franck Carbonnel and Yahya Mahamat-Saleh and Rudolf Kaaks and Tilman K{\"u}hn and Heiner Boeing and Antonia Trichopoulou and Elissavet Valanou and Effie Vasilopoulou and Giovanna Masala and Valeria Pala and Salvatore Panico and Rosario Tumino and Fulvio Ricceri and Elisabete Weiderpass and Marko Lukic and Sandanger, {Torkjel M} and Cristina Lasheras and Antonio Agudo and Maria-Jose S{\'a}nchez and Pilar Amiano and Carmen Navarro and Eva Ardanaz and Emily Sonestedt and Bodil Ohlsson and Nilsson, {Lena Maria} and Martin Ruteg{\aa}rd and Bas Bueno-de-Mesquita and Peeters, {Petra H} and Kay-Thee Khaw and Wareham, {Nicholas J} and Kathryn Bradbury and Heinz Freisling and Isabelle Romieu and Cross, {Amanda J} and Paolo Vineis and Augustin Scalbert",
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T1 - Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

AU - Zamora-Ros, Raul

AU - Cayssials, Valerie

AU - Jenab, Mazda

AU - Rothwell, Joseph A

AU - Fedirko, Veronika

AU - Aleksandrova, Krasimira

AU - Tjønneland, Anne

AU - Kyrø, Cecilie

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Carbonnel, Franck

AU - Mahamat-Saleh, Yahya

AU - Kaaks, Rudolf

AU - Kühn, Tilman

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Valanou, Elissavet

AU - Vasilopoulou, Effie

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Weiderpass, Elisabete

AU - Lukic, Marko

AU - Sandanger, Torkjel M

AU - Lasheras, Cristina

AU - Agudo, Antonio

AU - Sánchez, Maria-Jose

AU - Amiano, Pilar

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Sonestedt, Emily

AU - Ohlsson, Bodil

AU - Nilsson, Lena Maria

AU - Rutegård, Martin

AU - Bueno-de-Mesquita, Bas

AU - Peeters, Petra H

AU - Khaw, Kay-Thee

AU - Wareham, Nicholas J

AU - Bradbury, Kathryn

AU - Freisling, Heinz

AU - Romieu, Isabelle

AU - Cross, Amanda J

AU - Vineis, Paolo

AU - Scalbert, Augustin

PY - 2018/5/15

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N2 - Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.

AB - Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.

U2 - 10.1007/s10654-018-0408-6

DO - 10.1007/s10654-018-0408-6

M3 - Article

C2 - 29761424

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

ER -