Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only

E. Tremoli, A. Petroni, A. Socini, P. Maderna, S. Colli, R. Paoletti, C. Galli, A. Ferro-Luzzi, P. Strazzullo, M. Mancini, P. Puska, J. Iacono, R. Dougherty

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/ saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalAtherosclerosis
Volume59
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

Thromboxane B2
Finland
Italy
Blood Platelets
Diet
LDL Cholesterol
Fatty Acids
Unsaturated Fatty Acids
HDL Cholesterol
Collagen
Fats
Cholesterol
Lipids

Keywords

  • Dietary lipids
  • Lipoproteins
  • Platelets
  • Thromboxane B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only. / Tremoli, E.; Petroni, A.; Socini, A.; Maderna, P.; Colli, S.; Paoletti, R.; Galli, C.; Ferro-Luzzi, A.; Strazzullo, P.; Mancini, M.; Puska, P.; Iacono, J.; Dougherty, R.

In: Atherosclerosis, Vol. 59, No. 2, 1986, p. 101-111.

Research output: Contribution to journalArticle

Tremoli, E, Petroni, A, Socini, A, Maderna, P, Colli, S, Paoletti, R, Galli, C, Ferro-Luzzi, A, Strazzullo, P, Mancini, M, Puska, P, Iacono, J & Dougherty, R 1986, 'Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only', Atherosclerosis, vol. 59, no. 2, pp. 101-111. https://doi.org/10.1016/0021-9150(86)90038-9
Tremoli, E. ; Petroni, A. ; Socini, A. ; Maderna, P. ; Colli, S. ; Paoletti, R. ; Galli, C. ; Ferro-Luzzi, A. ; Strazzullo, P. ; Mancini, M. ; Puska, P. ; Iacono, J. ; Dougherty, R. / Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only. In: Atherosclerosis. 1986 ; Vol. 59, No. 2. pp. 101-111.
@article{f5d8bfdef35a4eeeb7bf9fa7c637000d,
title = "Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only",
abstract = "The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/ saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men.",
keywords = "Dietary lipids, Lipoproteins, Platelets, Thromboxane B",
author = "E. Tremoli and A. Petroni and A. Socini and P. Maderna and S. Colli and R. Paoletti and C. Galli and A. Ferro-Luzzi and P. Strazzullo and M. Mancini and P. Puska and J. Iacono and R. Dougherty",
year = "1986",
doi = "10.1016/0021-9150(86)90038-9",
language = "English",
volume = "59",
pages = "101--111",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Dietary Interventions in North Karelia, Finland and South Italy Modification of thromboxane B2 formation in platelets of male subjects only

AU - Tremoli, E.

AU - Petroni, A.

AU - Socini, A.

AU - Maderna, P.

AU - Colli, S.

AU - Paoletti, R.

AU - Galli, C.

AU - Ferro-Luzzi, A.

AU - Strazzullo, P.

AU - Mancini, M.

AU - Puska, P.

AU - Iacono, J.

AU - Dougherty, R.

PY - 1986

Y1 - 1986

N2 - The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/ saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men.

AB - The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/ saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men.

KW - Dietary lipids

KW - Lipoproteins

KW - Platelets

KW - Thromboxane B

UR - http://www.scopus.com/inward/record.url?scp=0022638750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022638750&partnerID=8YFLogxK

U2 - 10.1016/0021-9150(86)90038-9

DO - 10.1016/0021-9150(86)90038-9

M3 - Article

C2 - 3964338

AN - SCOPUS:0022638750

VL - 59

SP - 101

EP - 111

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -