Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats

F. Scopesi, C. M. Verkeste, D. Paola, D. Gazzolo, M. A. Pronzato, P. L. Bruschettini, U. M. Marinari

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study was designed to test if dietary intake of nucleotides increases erythrocyte 2,3-diphosphoglycerate (2,3-DPG) in neonatal rats. To this end, rat pups were fed a nucleotide-supplemented formula (S, n = 14) from d 9 until d 16 after birth. The results were compared with those obtained from a group of breast-fed pups (C, n = 14) and a group of pups artificially fed with nucleotide-free formula (NS, n = 14). Neonatal weight, 2,3-DPG concentration, hematocrit (Hct) and hemoglobin concentration (Hb) were determined before the experiment (d 9) and after 7 d of treatment (d 16). In all groups, 2,3-DPG concentration was greater at d 16 than d 9, and the increase was greater in the S group than in the NS group. Alterations in neonatal weight, Hct and Hb concentration did not differ among the groups. On d 16 the 2,3-DPG/Hb ratio, reflecting the affinity of hemoglobin for oxygen, was significantly higher in the C and S groups than in the NS group. We conclude that in neonatal rats, dietary nucleotides increase erythrocyte 2,3- DPG concentration. Studies need to be conducted in humans to assess the effect of this increase on both neonatal peripheral hemodynamics and metabolism in this species.

Original languageEnglish
Pages (from-to)662-665
Number of pages4
JournalJournal of Nutrition
Volume129
Issue number3
Publication statusPublished - 1999

Fingerprint

2,3-Diphosphoglycerate
Dietary Supplements
neonates
erythrocytes
Nucleotides
Erythrocytes
nucleotides
pups
hematocrit
hemoglobin
Hematocrit
Hemoglobins
hemodynamics
Weights and Measures
breasts
food intake
oxygen
Breast
Hemodynamics
metabolism

Keywords

  • Artificial feeding
  • Erythrocyte oxygen affinity
  • Nucleotides
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Scopesi, F., Verkeste, C. M., Paola, D., Gazzolo, D., Pronzato, M. A., Bruschettini, P. L., & Marinari, U. M. (1999). Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats. Journal of Nutrition, 129(3), 662-665.

Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats. / Scopesi, F.; Verkeste, C. M.; Paola, D.; Gazzolo, D.; Pronzato, M. A.; Bruschettini, P. L.; Marinari, U. M.

In: Journal of Nutrition, Vol. 129, No. 3, 1999, p. 662-665.

Research output: Contribution to journalArticle

Scopesi, F, Verkeste, CM, Paola, D, Gazzolo, D, Pronzato, MA, Bruschettini, PL & Marinari, UM 1999, 'Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats', Journal of Nutrition, vol. 129, no. 3, pp. 662-665.
Scopesi F, Verkeste CM, Paola D, Gazzolo D, Pronzato MA, Bruschettini PL et al. Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats. Journal of Nutrition. 1999;129(3):662-665.
Scopesi, F. ; Verkeste, C. M. ; Paola, D. ; Gazzolo, D. ; Pronzato, M. A. ; Bruschettini, P. L. ; Marinari, U. M. / Dietary nucleotide supplementation raises erythrocyte 2,3- diphosphoglycerate concentration in neonatal rats. In: Journal of Nutrition. 1999 ; Vol. 129, No. 3. pp. 662-665.
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