Dietary patterns and breast cancer risk: Results from three cohort studies in the DIETSCAN project

Satu Männistö, L. Beth Dixon, Helena F. Balder, Mikko J. Virtanen, Vittorio Krogh, Bahram Rashid Khani, Franco Berrino, Piet A. Van Den Brandt, Anne M. Hartman, Pirjo Pietinen, Frans Tan, Alicja Wolk, R. Alexandra Goldbohm

Research output: Contribution to journalArticle

Abstract

Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast cancer. It is also important to examine whether the relationships between dietary patterns and breast cancer risk are consistent across populations. Methods: We examined the risk of breast cancer with two dietary patterns, identified as "Vegetables" (VEG) and "Pork, Processed Meat, Potatoes" (PPP), common to all cohorts of the DIETSCAN project. During 7 to 13 years of follow-up, three of the cohorts - the Netherlands Cohort Study on diet and cancer (NLCS), the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET) - provided data on 3271 breast cancer cases with complete information on their baseline diet measured by a validated food frequency questionnaire. Results: After adjustment for potential confounders, VEG was not associated with the risk of breast cancer across all cohorts. PPP was also not associated with the risk of breast cancer in SMC and ORDET, but a high PPP score tended to be inversely associated with breast cancer in the NLCS study (RR = 0.69; 95% CI, 0.52-0.92, highest versus lowest quartile). PPP differed in one aspect between the cohorts: butter loaded positively on the pattern in all cohorts except NLCS, in which butter loaded negatively and appeared to be substituted by low-fat margarine loading positively. Conclusion: In general, the dietary patterns showed consistent results across the three cohorts except for the possible protective effect of PPP in the NLCS cohort, which could be explained by a difference in that pattern for NLCS. The results supported the suggestion derived from traditional epidemiology that relatively recent diet may not have an important role in the etiology of breast cancer.

Original languageEnglish
Pages (from-to)725-733
Number of pages9
JournalCancer Causes and Control
Volume16
Issue number6
DOIs
Publication statusPublished - Aug 2005

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Cohort Studies
Breast Neoplasms
Solanum tuberosum
Meat
Diet
Food
Butter
Mammography
Vegetables
Margarine
Netherlands
Italy
Epidemiology
Fats
Red Meat
Population
Neoplasms

Keywords

  • Breast cancer
  • Diet
  • Dietary pattern
  • Factor analysis
  • Principal component analysis

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Männistö, S., Dixon, L. B., Balder, H. F., Virtanen, M. J., Krogh, V., Khani, B. R., ... Goldbohm, R. A. (2005). Dietary patterns and breast cancer risk: Results from three cohort studies in the DIETSCAN project. Cancer Causes and Control, 16(6), 725-733. https://doi.org/10.1007/s10552-005-1763-7

Dietary patterns and breast cancer risk : Results from three cohort studies in the DIETSCAN project. / Männistö, Satu; Dixon, L. Beth; Balder, Helena F.; Virtanen, Mikko J.; Krogh, Vittorio; Khani, Bahram Rashid; Berrino, Franco; Van Den Brandt, Piet A.; Hartman, Anne M.; Pietinen, Pirjo; Tan, Frans; Wolk, Alicja; Goldbohm, R. Alexandra.

In: Cancer Causes and Control, Vol. 16, No. 6, 08.2005, p. 725-733.

Research output: Contribution to journalArticle

Männistö, S, Dixon, LB, Balder, HF, Virtanen, MJ, Krogh, V, Khani, BR, Berrino, F, Van Den Brandt, PA, Hartman, AM, Pietinen, P, Tan, F, Wolk, A & Goldbohm, RA 2005, 'Dietary patterns and breast cancer risk: Results from three cohort studies in the DIETSCAN project', Cancer Causes and Control, vol. 16, no. 6, pp. 725-733. https://doi.org/10.1007/s10552-005-1763-7
Männistö, Satu ; Dixon, L. Beth ; Balder, Helena F. ; Virtanen, Mikko J. ; Krogh, Vittorio ; Khani, Bahram Rashid ; Berrino, Franco ; Van Den Brandt, Piet A. ; Hartman, Anne M. ; Pietinen, Pirjo ; Tan, Frans ; Wolk, Alicja ; Goldbohm, R. Alexandra. / Dietary patterns and breast cancer risk : Results from three cohort studies in the DIETSCAN project. In: Cancer Causes and Control. 2005 ; Vol. 16, No. 6. pp. 725-733.
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AU - Balder, Helena F.

AU - Virtanen, Mikko J.

AU - Krogh, Vittorio

AU - Khani, Bahram Rashid

AU - Berrino, Franco

AU - Van Den Brandt, Piet A.

AU - Hartman, Anne M.

AU - Pietinen, Pirjo

AU - Tan, Frans

AU - Wolk, Alicja

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N2 - Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast cancer. It is also important to examine whether the relationships between dietary patterns and breast cancer risk are consistent across populations. Methods: We examined the risk of breast cancer with two dietary patterns, identified as "Vegetables" (VEG) and "Pork, Processed Meat, Potatoes" (PPP), common to all cohorts of the DIETSCAN project. During 7 to 13 years of follow-up, three of the cohorts - the Netherlands Cohort Study on diet and cancer (NLCS), the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET) - provided data on 3271 breast cancer cases with complete information on their baseline diet measured by a validated food frequency questionnaire. Results: After adjustment for potential confounders, VEG was not associated with the risk of breast cancer across all cohorts. PPP was also not associated with the risk of breast cancer in SMC and ORDET, but a high PPP score tended to be inversely associated with breast cancer in the NLCS study (RR = 0.69; 95% CI, 0.52-0.92, highest versus lowest quartile). PPP differed in one aspect between the cohorts: butter loaded positively on the pattern in all cohorts except NLCS, in which butter loaded negatively and appeared to be substituted by low-fat margarine loading positively. Conclusion: In general, the dietary patterns showed consistent results across the three cohorts except for the possible protective effect of PPP in the NLCS cohort, which could be explained by a difference in that pattern for NLCS. The results supported the suggestion derived from traditional epidemiology that relatively recent diet may not have an important role in the etiology of breast cancer.

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