Dietary patterns and risk of breast cancer in the ORDET cohort

Sabina Sieri, Vittorio Krogh, Valeria Pala, Paola Muti, Andrea Micheli, Alberto Evangelista, Giovanna Tagliabue, Franco Berrino

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the association between dietary patterns and risk of developing breast cancer in an Italian cohort. Women volunteers were recruited from 1987 to 1992 from residents in Varese province, northern Italy, an area covered by a cancer registry. Participants completed a semiquantitative food frequency questionnaire, and anthropometric and other data were collected systematically. Using nutritional data from 8984 women with an average follow up of 9.5 years and 207 incident cases of breast cancer, we conducted an exploratory factor analysis to identify major dietary patterns. Four dietary patterns, which explained 30% of the variance, emerged: salad vegetables (mainly consisting of raw vegetables and olive oil); Western (mainly consisting of potatoes, red meat, eggs and butter); canteen (pasta and tomato sauce); and prudent (cooked vegetables, pulses, and fish, with negative loading on wines and spirits). After adjustment for potential confounders, only the salad vegetables pattern was associated with significantly lower (34-35%) breast cancer incidence (RR = 0.66, CI95% = 0.47±0.95 comparing highest with lowest tertile) with a significant linear trend (P = 0.016). Women with body mass index 50% less risk than the lowest tertile, RR = 0.39, CI95% = 0.22-0.69) with a significant trend (P = 0.001); whereas women with body mass index

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number4
Publication statusPublished - Apr 2004

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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