Abstract
Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European cohorts: the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (Finland-ATBC), the Netherlands Cohort Study (NLCS) on Diet and Cancer, the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET). Three cohorts (ATBC, NLCS, and SMC) provided data on colon and rectal cancer for the present study. Design: The cohorts were established between 1985 and 1992; follow-up data were obtained from national cancer registries. The participants completed validated semiquantitative food-frequency questionnaires at baseline. Results: Exploratory factor analysis, conducted within each cohort, identified 3-5 stable dietary patterns. Two dietary patterns - Vegetables and Pork, Processed Meats, Potatoes (PPP) - were common across all cohorts. After adjustment for potential confounders, PPP was associated with an increased risk of colon cancer in the SMC women (quintile4 multivariate relative risk: 1.62; 95% CI: 1.12,2.34; P for trend = 0.01). PPP was also associated with an increased risk of rectal cancer in the ATBC men (quintile 4 multivariate relative risk: 2.21; 95% CI: 1.07, 4.57; P for trend = 0.05). Neither pattern was associated with the risk of colon or rectal cancer in the NLCS women and men. Conclusion: Although certain dietary patterns may be consistent across European countries, associations between these dietary patterns and the risk of colon and rectal cancer are not conclusive.
| Original language | English |
|---|---|
| Pages (from-to) | 1003-1011 |
| Number of pages | 9 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 80 |
| Issue number | 4 |
| Publication status | Published - Oct 2004 |
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Keywords
- Colorectal cancer
- Dietary pattern
- Dietary Patterns and Cancer Project
- DIETSCAN
- Factor analysis
- Principal components analysis
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Dietary patterns associated with colon and rectal cancer : Results from the Dietary Patterns and Cancer (DIETSCAN) Project. / Dixon, L. Beth; Balder, Helena F.; Virtanen, Mikko J.; Rashidkhani, Bahram; Männistö, Satu; Krogh, Vittorio; Van Den Brandt, Piet A.; Hartman, Anne M.; Pietinen, Pirjo; Tan, Frans; Virtamo, Jarmo; Wolk, Alicja; Goldbohm, R. Alexandra.
In: American Journal of Clinical Nutrition, Vol. 80, No. 4, 10.2004, p. 1003-1011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dietary patterns associated with colon and rectal cancer
T2 - Results from the Dietary Patterns and Cancer (DIETSCAN) Project
AU - Dixon, L. Beth
AU - Balder, Helena F.
AU - Virtanen, Mikko J.
AU - Rashidkhani, Bahram
AU - Männistö, Satu
AU - Krogh, Vittorio
AU - Van Den Brandt, Piet A.
AU - Hartman, Anne M.
AU - Pietinen, Pirjo
AU - Tan, Frans
AU - Virtamo, Jarmo
AU - Wolk, Alicja
AU - Goldbohm, R. Alexandra
PY - 2004/10
Y1 - 2004/10
N2 - Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European cohorts: the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (Finland-ATBC), the Netherlands Cohort Study (NLCS) on Diet and Cancer, the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET). Three cohorts (ATBC, NLCS, and SMC) provided data on colon and rectal cancer for the present study. Design: The cohorts were established between 1985 and 1992; follow-up data were obtained from national cancer registries. The participants completed validated semiquantitative food-frequency questionnaires at baseline. Results: Exploratory factor analysis, conducted within each cohort, identified 3-5 stable dietary patterns. Two dietary patterns - Vegetables and Pork, Processed Meats, Potatoes (PPP) - were common across all cohorts. After adjustment for potential confounders, PPP was associated with an increased risk of colon cancer in the SMC women (quintile4 multivariate relative risk: 1.62; 95% CI: 1.12,2.34; P for trend = 0.01). PPP was also associated with an increased risk of rectal cancer in the ATBC men (quintile 4 multivariate relative risk: 2.21; 95% CI: 1.07, 4.57; P for trend = 0.05). Neither pattern was associated with the risk of colon or rectal cancer in the NLCS women and men. Conclusion: Although certain dietary patterns may be consistent across European countries, associations between these dietary patterns and the risk of colon and rectal cancer are not conclusive.
AB - Background: An analysis of dietary patterns or combinations of foods may provide insight regarding the influence of diet on the risk of colon and rectal cancer. Objective: A primary aim of the Dietary Patterns and Cancer (DIETSCAN) Project was to develop and apply a common methodologic approach to study dietary patterns and cancer in 4 European cohorts: the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study (Finland-ATBC), the Netherlands Cohort Study (NLCS) on Diet and Cancer, the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET). Three cohorts (ATBC, NLCS, and SMC) provided data on colon and rectal cancer for the present study. Design: The cohorts were established between 1985 and 1992; follow-up data were obtained from national cancer registries. The participants completed validated semiquantitative food-frequency questionnaires at baseline. Results: Exploratory factor analysis, conducted within each cohort, identified 3-5 stable dietary patterns. Two dietary patterns - Vegetables and Pork, Processed Meats, Potatoes (PPP) - were common across all cohorts. After adjustment for potential confounders, PPP was associated with an increased risk of colon cancer in the SMC women (quintile4 multivariate relative risk: 1.62; 95% CI: 1.12,2.34; P for trend = 0.01). PPP was also associated with an increased risk of rectal cancer in the ATBC men (quintile 4 multivariate relative risk: 2.21; 95% CI: 1.07, 4.57; P for trend = 0.05). Neither pattern was associated with the risk of colon or rectal cancer in the NLCS women and men. Conclusion: Although certain dietary patterns may be consistent across European countries, associations between these dietary patterns and the risk of colon and rectal cancer are not conclusive.
KW - Colorectal cancer
KW - Dietary pattern
KW - Dietary Patterns and Cancer Project
KW - DIETSCAN
KW - Factor analysis
KW - Principal components analysis
UR - http://www.scopus.com/inward/record.url?scp=5144226554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5144226554&partnerID=8YFLogxK
M3 - Article
C2 - 15447912
AN - SCOPUS:5144226554
VL - 80
SP - 1003
EP - 1011
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -