Dietary phytoestrogen intake is inversely associated with hypertension in a cohort of adults living in the mediterranean area

Justyna Godos, Sonia Bergante, Angela Satriano, Francesca Romana Pluchinotta, Marina Marranzano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Dietary polyphenols, including phytoestrogens are abundantly present in a balanced diet. Evidence for their role in preventing non-communicable diseases is emerging. Methods: We examined the association between estimated habitual intakes of dietary phytoestrogens and hypertension in a cohort study. The baseline data included 1936 men and women aged 18 years and older. Intakes of total phytoestrogens, isoflavones, and lignans were calculated from validated food frequency questionnaire. Data on the polyphenols content in foods were retrieved from the Phenol-Explorer database. Results: Individuals in the highest quartile of dietary phytoestrogens intake were less likely to be hypertensive (OR: 0.66, 95% CI: 0.44-0.98); moreover, the association showed a significant decreasing trend. Isoflavones and lignans were not associated with lower odds of hypertension; however, some individual compounds, such as biochanin A and pinoresinol showed an independent inverse association with hypertension. Conclusions: Dietary phytoestrogens are associated with lower likelihood of hypertension in adults living in the Mediterranean area. Future studies are needed to confirm the present findings (i.e., prospective cohort studies) and to better understand the mechanisms underlying such associations.

Original languageEnglish
Article number368
JournalMolecules
Volume23
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Blood pressure
  • CVD
  • Hypertension
  • Isoflavone
  • Lignan
  • Meditteranean cohort
  • Phytoestrogen

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Dietary phytoestrogen intake is inversely associated with hypertension in a cohort of adults living in the mediterranean area'. Together they form a unique fingerprint.

Cite this