Dietary polyphenols and regulation of gelatinase expression and activity

Mario Dell'Agli, Monica Canavesi, Germana Galli, Stefano Bellosta

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of cells with the extracellular matrix (ECM) is critical for the normal development and function of organisms. The matrix metalloproteinases (MMPs) are a family of Zn++ and Ca++ dependent endopeptidases, which are key mediators of ECM remodelling.The turnover and remodelling of ECM must be tightly regulated, since uncontrolled proteolysis would contribute to abnormal development and to the generation of many pathological conditions characterized by either excessive degradation, or lack of degradation of ECM components. In particular, the gelatinases (MMP-2 and -9) are abundantly expressed in various malignant tumors, play an active role in angiogenesis, and may also influence the process of atherosclerotic lesion formation. In recent years, much consideration has been given to the role of diet in preventing degenerative diseases, such as cancer and cardiovascular diseases. Polyphenols are abundant components /micronutrients of the human diet that have been shown in vitro to profoundly affect ECM turnover by regulating gelatinases expression and activity, acting at both the pre- and post-transcriptional level. Therefore, they could have a beneficial effect in many pathological conditions implicated in connective tissue destruction and remodelling associated with degenerative diseases.

Original languageEnglish
Pages (from-to)751-760
Number of pages10
JournalThrombosis and Haemostasis
Volume93
Issue number4
DOIs
Publication statusPublished - Apr 2005

Keywords

  • Dietary polyphenols
  • Gelatinase
  • Gene regulation
  • Matrix turnover
  • Metalloproteinases

ASJC Scopus subject areas

  • Hematology

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