Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing

T. Armeni, M. Tomasetti, S. Svegliati Baroni, F. Saccucci, M. Marra, C. Pieri, G. P. Littarru, G. Principato, M. Battino

Research output: Contribution to journalArticlepeer-review

Abstract

Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by age and dietary treatment. Coenzyme Q9 and CoQ10 showed the highest levels in the oldest rats where ageing, as well as other oxidative stresses, could induce ubiquinone biosynthesis.

Original languageEnglish
JournalMolecular Aspects of Medicine
Volume18
Issue numberSUPPL.
DOIs
Publication statusPublished - 1997

Keywords

  • Coenzyme Q
  • Dietary restriction
  • Glutathione
  • Rat liver mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

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