Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease

M. T. Armentero, G. Levandis, P. Bramanti, G. Nappi, F. Blandini

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Abstract

Chronic reduction of the caloric intake is associated with extended lifespan, in rodents, and has been proposed to counteract neuronal loss in animal models of neurodegeneration. To test this hypothesis, we investigated the effect of dietary restriction (DR) in a rodent model of Parkinson's disease, based on the intrastriatal infusion of 6-hydroxydopamine. We could not confirm the neuroprotective effect of DR previously suggested: histological and behavioral measures indicated similar degrees of dopaminergic neuron loss in rats maintained on DR - for two or eight weeks prior to the lesion - or with free access to food.

Original languageEnglish
Pages (from-to)548-551
Number of pages4
JournalExperimental Neurology
Volume212
Issue number2
DOIs
Publication statusPublished - Aug 2008

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Oxidopamine
Parkinson Disease
Rodentia
Dopaminergic Neurons
Neuroprotective Agents
Energy Intake
Animal Models
Food

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease. / Armentero, M. T.; Levandis, G.; Bramanti, P.; Nappi, G.; Blandini, F.

In: Experimental Neurology, Vol. 212, No. 2, 08.2008, p. 548-551.

Research output: Contribution to journalArticle

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