Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma.

Jinfu Hu, Carlo La Vecchia, Eva Negri, Marie DesMeules, Les Mery, Cancer Registries Epidemiology Research Group Canadian Cancer Registries Epidemiology Research Group

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECT: The study examines the association between dietary intake of vitamin C, E, and carotenoids and the risk of renal cell carcinoma (RCC). METHODS: Between 1994 and 1997 in 8 Canadian provinces, mailed questionnaires were completed by 1,138 incident, histologically confirmed cases of RCC and 5,039 population controls, including information on socio-economic status, lifestyle habits and diet. A 69-item food frequency questionnaire provided data on eating habits 2 years before data collection. Odds ratios (OR) and 95% confidence intervals (CI) were computed using unconditional logistic regression. RESULTS: Dietary intake of beta-carotene and lutein/zeaxanthin was inversely associated with the risk of RCC. The ORs for the highest versus the lowest quartile were 0.74 (95% CI, 0.59-0.92) and 0.77 (95% CI, 0.62-0.95), respectively. The significant inverse association with beta-carotene and lutein/zeaxanthin was more pronounced in women, and in overweight or obese subjects. The relation of lutein/zeaxanthin to RCC was stronger in ever smokers. No clear association was observed with vitamin C and E, beta-cryptozanthin, and lycopene. CONCLUSION: The findings provide evidence that a diet rich in beta-carotene and lutein/zeaxanthin may play a role in RCC prevention.

Original languageEnglish
Pages (from-to)1451-1458
Number of pages8
JournalCancer Causes and Control
Volume20
Issue number8
DOIs
Publication statusPublished - Oct 2009

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Carotenoids
Lutein
Vitamin E
Renal Cell Carcinoma
Ascorbic Acid
beta Carotene
Feeding Behavior
Confidence Intervals
Population Control
Life Style
Logistic Models
Odds Ratio
Economics
Diet
Food
Zeaxanthins
Surveys and Questionnaires

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hu, J., La Vecchia, C., Negri, E., DesMeules, M., Mery, L., & Canadian Cancer Registries Epidemiology Research Group, C. R. E. R. G. (2009). Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma. Cancer Causes and Control, 20(8), 1451-1458. https://doi.org/10.1007/s10552-009-9371-6

Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma. / Hu, Jinfu; La Vecchia, Carlo; Negri, Eva; DesMeules, Marie; Mery, Les; Canadian Cancer Registries Epidemiology Research Group, Cancer Registries Epidemiology Research Group.

In: Cancer Causes and Control, Vol. 20, No. 8, 10.2009, p. 1451-1458.

Research output: Contribution to journalArticle

Hu, J, La Vecchia, C, Negri, E, DesMeules, M, Mery, L & Canadian Cancer Registries Epidemiology Research Group, CRERG 2009, 'Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma.', Cancer Causes and Control, vol. 20, no. 8, pp. 1451-1458. https://doi.org/10.1007/s10552-009-9371-6
Hu J, La Vecchia C, Negri E, DesMeules M, Mery L, Canadian Cancer Registries Epidemiology Research Group CRERG. Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma. Cancer Causes and Control. 2009 Oct;20(8):1451-1458. https://doi.org/10.1007/s10552-009-9371-6
Hu, Jinfu ; La Vecchia, Carlo ; Negri, Eva ; DesMeules, Marie ; Mery, Les ; Canadian Cancer Registries Epidemiology Research Group, Cancer Registries Epidemiology Research Group. / Dietary vitamin C, E, and carotenoid intake and risk of renal cell carcinoma. In: Cancer Causes and Control. 2009 ; Vol. 20, No. 8. pp. 1451-1458.
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