Dietary vitamin D and cancers of the oral cavity and esophagus

Loren Lipworth, M. Rossi, J. K. McLaughlin, E. Negri, R. Talamini, F. Levi, S. Franceschi, C. La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Data on the association between vitamin D and upper digestive tract neoplasms are limited. Methods: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. Results: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/ pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank

Original languageEnglish
Pages (from-to)1576-1581
Number of pages6
JournalAnnals of Oncology
Volume20
Issue number9
DOIs
Publication statusPublished - 2009

Keywords

  • Cancer
  • Epidemiology
  • Esophageal
  • Oral
  • Pharyngeal
  • Vitamin D

ASJC Scopus subject areas

  • Oncology
  • Hematology

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