Dietary Vitamin E as a protective factor for Parkinson's disease

Clinical and experimental evidence

Tommaso Schirinzi, Giuseppina Martella, Paola Imbriani, Giulia Di Lazzaro, Donatella Franco, Vito Luigi Colona, Mohammad Alwardat, Paola Sinibaldi Salimei, Nicola Biagio Mercuri, Mariangela Pierantozzi, Antonio Pisani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative successful strategy is to counteract oxidative stress, not only with synthetic compounds, but also with natural agents or dietary choices. Vitamin E, in particular, is a powerful antioxidant, commonly found in vegetables and other components of the diet. In this work, we performed a questionnaire based case-control study on 100 PD patients and 100 healthy controls. The analysis showed that a higher dietary intake of Vitamin E was inversely associated with PD occurrence independently from age and gender (OR = 1.022; 95% CI = 0.999-1.045; p < 0.05), though unrelated to clinical severity. Then, in order to provide a mechanistic explanation for such observation, we tested the effects of Vitamin E and other alimentary antioxidants in vitro, by utilizing the homozygous PTEN-induced kinase 1 knockout (PINK1 -/- ) mouse model of PD. PINK1 -/- mice exhibit peculiar alterations of synaptic plasticity at corticostriatal synapses, consisting in the loss of both long-term potentiation (LTP) and long-term depression (LTD), in the absence of overt neurodegeneration. Chronic administration of Vitamin E (alpha-tocopherol and the water-soluble analog trolox) fully restored corticostriatal synaptic plasticity in PINK1 -/- mice, suggestive of a specific protective action. Vitamin E might indeed compensate PINK1 haploinsufficiency and mitochondrial impairment, reverting some central steps of the pathogenic process. Altogether, both clinical and experimental findings suggest that Vitamin E could be a potential, useful agent for PD patients. These data, although preliminary, may encourage future confirmatory trials.

Original languageEnglish
Article number148
JournalFrontiers in Neurology
Volume10
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Parkinsonian Disorders
Vitamin E
Parkinson Disease
Neuronal Plasticity
Antioxidants
Haploinsufficiency
Long-Term Potentiation
alpha-Tocopherol
Knockout Mice
Vegetables
Synapses
Protective Factors
Case-Control Studies
Oxidative Stress
Phosphotransferases
Observation
Diet
Water

Keywords

  • Antioxidant
  • Diet
  • Neuroprotection
  • Parkinson's disease
  • PINK1
  • Protective factors
  • Synaptic plasticity
  • Vitamin E

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Dietary Vitamin E as a protective factor for Parkinson's disease : Clinical and experimental evidence. / Schirinzi, Tommaso; Martella, Giuseppina; Imbriani, Paola; Di Lazzaro, Giulia; Franco, Donatella; Colona, Vito Luigi; Alwardat, Mohammad; Salimei, Paola Sinibaldi; Mercuri, Nicola Biagio; Pierantozzi, Mariangela; Pisani, Antonio.

In: Frontiers in Neurology, Vol. 10, 148, 01.01.2019.

Research output: Contribution to journalArticle

Schirinzi, T, Martella, G, Imbriani, P, Di Lazzaro, G, Franco, D, Colona, VL, Alwardat, M, Salimei, PS, Mercuri, NB, Pierantozzi, M & Pisani, A 2019, 'Dietary Vitamin E as a protective factor for Parkinson's disease: Clinical and experimental evidence', Frontiers in Neurology, vol. 10, 148. https://doi.org/10.3389/fneur.2019.00148
Schirinzi, Tommaso ; Martella, Giuseppina ; Imbriani, Paola ; Di Lazzaro, Giulia ; Franco, Donatella ; Colona, Vito Luigi ; Alwardat, Mohammad ; Salimei, Paola Sinibaldi ; Mercuri, Nicola Biagio ; Pierantozzi, Mariangela ; Pisani, Antonio. / Dietary Vitamin E as a protective factor for Parkinson's disease : Clinical and experimental evidence. In: Frontiers in Neurology. 2019 ; Vol. 10.
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