Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy

Silvano Gallus, Roberto Foschi, Eva Negri, Renato Talamini, Silvia Franceschi, Maurizio Montella, Valerio Ramazzotti, Alessandra Tavani, Luigino Dal Maso, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Objectives: Zinc concentration is higher in the prostate than in most other tissues. Since information on the role of zinc on prostate carcinogenesis is controversial, we analysed the issue in a case-control study. Methods: Between 1991 and 2002, we conducted a multicentre hospital-based case-control study on prostate cancer in Italy. Cases included 1294 men with incident, histologically confirmed prostate cancer. Controls included 1451 patients admitted to the same hospitals as cases for a wide spectrum of acute non-neoplastic, non-hormone-related diseases. Zinc intake was computed from a valid and reproducible food frequency questionnaire, with the use of an Italian food composition database. Odds ratios (OR) of dietary intake of zinc and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models, after allowance for several covariates, including total energy. Results: Compared with the lowest quintile, the OR for the highest quintile was 1.56 (95% CI, 1.07-2.26), with a significant trend in risk (p = 0.04). The trend in risk was significant for advanced cancers only, the OR being 2.02 (95% CI, 1.14-3.59) for prostate cancers with a high Gleason score. Conclusions: In this large study we found a direct association between high zinc intake and prostate cancer risk, particularly for advanced cancers. Our findings allow one to exclude a favourable effect of zinc on prostate carcinogenesis.

Original languageEnglish
Pages (from-to)1052-1057
Number of pages6
JournalEuropean Urology
Volume52
Issue number4
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Italy
Case-Control Studies
Zinc
Prostatic Neoplasms
Prostate
Odds Ratio
Confidence Intervals
Carcinogenesis
Logistic Models
Food
Neoplasm Grading
Neoplasms
Databases

Keywords

  • Case-control study
  • Diet
  • Prostate cancer
  • Risk factors
  • Zinc

ASJC Scopus subject areas

  • Urology

Cite this

Gallus, S., Foschi, R., Negri, E., Talamini, R., Franceschi, S., Montella, M., ... La Vecchia, C. (2007). Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy. European Urology, 52(4), 1052-1057. https://doi.org/10.1016/j.eururo.2007.01.094

Dietary Zinc and Prostate Cancer Risk : A Case-Control Study from Italy. / Gallus, Silvano; Foschi, Roberto; Negri, Eva; Talamini, Renato; Franceschi, Silvia; Montella, Maurizio; Ramazzotti, Valerio; Tavani, Alessandra; Dal Maso, Luigino; La Vecchia, Carlo.

In: European Urology, Vol. 52, No. 4, 10.2007, p. 1052-1057.

Research output: Contribution to journalArticle

Gallus, S, Foschi, R, Negri, E, Talamini, R, Franceschi, S, Montella, M, Ramazzotti, V, Tavani, A, Dal Maso, L & La Vecchia, C 2007, 'Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy', European Urology, vol. 52, no. 4, pp. 1052-1057. https://doi.org/10.1016/j.eururo.2007.01.094
Gallus, Silvano ; Foschi, Roberto ; Negri, Eva ; Talamini, Renato ; Franceschi, Silvia ; Montella, Maurizio ; Ramazzotti, Valerio ; Tavani, Alessandra ; Dal Maso, Luigino ; La Vecchia, Carlo. / Dietary Zinc and Prostate Cancer Risk : A Case-Control Study from Italy. In: European Urology. 2007 ; Vol. 52, No. 4. pp. 1052-1057.
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