Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve

Salvatore Pasta, Antonino Rinaudo, Angelo Luca, Michele Pilato, Cesare Scardulla, Thomas G. Gleason, David A. Vorp

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The aortic dissection (AoD) of an ascending thoracic aortic aneurysm (ATAA) initiates when the hemodynamic loads exerted on the aneurysmal wall overcome the adhesive forces holding the elastic layers together. Parallel coupled, two-way fluid-structure interaction (FSI) analyses were performed on patient-specific ATAAs obtained from patients with either bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) to evaluate hemodynamic predictors and wall stresses imparting aneurysm enlargement and AoD. Results showed a left-handed circumferential flow with slower-moving helical pattern in the aneurysm's center for BAV ATAAs whereas a slight deviation of the blood flow toward the anterolateral region of the ascending aorta was observed for TAV ATAAs. Blood pressure and wall shear stress were found key hemodynamic predictors of aneurysm dilatation, and their dissimilarities are likely associated to the morphological anatomy of the aortic valve. We also observed discontinues, wall stresses on aneurysmal aorta, which was modeled as a composite with two elastic layers (i.e., inhomogeneity of vessel structural organization). This stress distribution was caused by differences on elastic material properties of aortic layers. Wall stress distribution suggests AoD just above sinotubular junction. Moreover, abnormal flow and lower elastic material properties that are likely intrinsic in BAV individuals render the aneurysm susceptible to the initiation of AoD.

Original languageEnglish
Pages (from-to)1729-1738
Number of pages10
JournalJournal of Biomechanics
Volume46
Issue number10
DOIs
Publication statusPublished - Jun 21 2013

Fingerprint

Thoracic Aortic Aneurysm
Dissection
Tricuspid Valve
Hemodynamics
Aortic Valve
Aneurysm
Aorta
Stress concentration
Materials properties
Aortic Aneurysm
Fluid structure interaction
Blood pressure
Adhesives
Shear stress
Dilatation
Anatomy
Blood
Blood Pressure
Bicuspid Aortic Valve
Composite materials

Keywords

  • Aortic dissection
  • Ascending thoracic aortic aneurysm
  • Bicuspid aortic valve
  • Fluid-structure interaction

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve. / Pasta, Salvatore; Rinaudo, Antonino; Luca, Angelo; Pilato, Michele; Scardulla, Cesare; Gleason, Thomas G.; Vorp, David A.

In: Journal of Biomechanics, Vol. 46, No. 10, 21.06.2013, p. 1729-1738.

Research output: Contribution to journalArticle

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