Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism

Elisa Di Giorgio, Elisa Frasnelli, Orsola Rosa Salva, Scattoni Maria Luisa, M. Puopolo, Daniela Tosoni, Francesca Simion, Giorgio Vallortigara, Fabio Apicella, Antonella Gagliano, Andrea Guzzetta, Massimo Molteni, Antonio Maria Persico, G. Pioggia, Giovanni Valeri, Stefano Vicari, Francesca Simion, Giorgio Vallortigara

Research output: Contribution to journalArticle

Abstract

Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is usually not diagnosed until a child is at least 3 years old. Here, we circumvented this difficulty by studying for the very first time, the predispositions to pay attention to social stimuli in newborns with a high familial risk of autism. Results showed that visual preferences to social stimuli strikingly differed between high-risk and low-risk newborns. Significant predictors for high-risk newborns were obtained and an accurate biomarker was identified. The results revealed early behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approach to the emergence of autism in early infancy.

Original languageEnglish
Article number26395
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - May 20 2016

Fingerprint

Autistic Disorder
Newborn Infant
Biomarkers
Autism Spectrum Disorder

ASJC Scopus subject areas

  • General

Cite this

Di Giorgio, E., Frasnelli, E., Rosa Salva, O., Maria Luisa, S., Puopolo, M., Tosoni, D., ... Vallortigara, G. (2016). Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism. Scientific Reports, 6, [26395]. https://doi.org/10.1038/srep26395

Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism. / Di Giorgio, Elisa; Frasnelli, Elisa; Rosa Salva, Orsola; Maria Luisa, Scattoni; Puopolo, M.; Tosoni, Daniela; Simion, Francesca; Vallortigara, Giorgio; Apicella, Fabio; Gagliano, Antonella; Guzzetta, Andrea; Molteni, Massimo; Persico, Antonio Maria; Pioggia, G.; Valeri, Giovanni; Vicari, Stefano; Simion, Francesca; Vallortigara, Giorgio.

In: Scientific Reports, Vol. 6, 26395, 20.05.2016.

Research output: Contribution to journalArticle

Di Giorgio, E, Frasnelli, E, Rosa Salva, O, Maria Luisa, S, Puopolo, M, Tosoni, D, Simion, F, Vallortigara, G, Apicella, F, Gagliano, A, Guzzetta, A, Molteni, M, Persico, AM, Pioggia, G, Valeri, G, Vicari, S, Simion, F & Vallortigara, G 2016, 'Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism', Scientific Reports, vol. 6, 26395. https://doi.org/10.1038/srep26395
Di Giorgio E, Frasnelli E, Rosa Salva O, Maria Luisa S, Puopolo M, Tosoni D et al. Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism. Scientific Reports. 2016 May 20;6. 26395. https://doi.org/10.1038/srep26395
Di Giorgio, Elisa ; Frasnelli, Elisa ; Rosa Salva, Orsola ; Maria Luisa, Scattoni ; Puopolo, M. ; Tosoni, Daniela ; Simion, Francesca ; Vallortigara, Giorgio ; Apicella, Fabio ; Gagliano, Antonella ; Guzzetta, Andrea ; Molteni, Massimo ; Persico, Antonio Maria ; Pioggia, G. ; Valeri, Giovanni ; Vicari, Stefano ; Simion, Francesca ; Vallortigara, Giorgio. / Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism. In: Scientific Reports. 2016 ; Vol. 6.
@article{eb12f0ce0ff1414abc8fcf7aef9b9eeb,
title = "Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism",
abstract = "Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is usually not diagnosed until a child is at least 3 years old. Here, we circumvented this difficulty by studying for the very first time, the predispositions to pay attention to social stimuli in newborns with a high familial risk of autism. Results showed that visual preferences to social stimuli strikingly differed between high-risk and low-risk newborns. Significant predictors for high-risk newborns were obtained and an accurate biomarker was identified. The results revealed early behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approach to the emergence of autism in early infancy.",
author = "{Di Giorgio}, Elisa and Elisa Frasnelli and {Rosa Salva}, Orsola and {Maria Luisa}, Scattoni and M. Puopolo and Daniela Tosoni and Francesca Simion and Giorgio Vallortigara and Fabio Apicella and Antonella Gagliano and Andrea Guzzetta and Massimo Molteni and Persico, {Antonio Maria} and G. Pioggia and Giovanni Valeri and Stefano Vicari and Francesca Simion and Giorgio Vallortigara",
year = "2016",
month = "5",
day = "20",
doi = "10.1038/srep26395",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Difference in Visual Social Predispositions between Newborns at Low-and High-risk for Autism

AU - Di Giorgio, Elisa

AU - Frasnelli, Elisa

AU - Rosa Salva, Orsola

AU - Maria Luisa, Scattoni

AU - Puopolo, M.

AU - Tosoni, Daniela

AU - Simion, Francesca

AU - Vallortigara, Giorgio

AU - Apicella, Fabio

AU - Gagliano, Antonella

AU - Guzzetta, Andrea

AU - Molteni, Massimo

AU - Persico, Antonio Maria

AU - Pioggia, G.

AU - Valeri, Giovanni

AU - Vicari, Stefano

AU - Simion, Francesca

AU - Vallortigara, Giorgio

PY - 2016/5/20

Y1 - 2016/5/20

N2 - Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is usually not diagnosed until a child is at least 3 years old. Here, we circumvented this difficulty by studying for the very first time, the predispositions to pay attention to social stimuli in newborns with a high familial risk of autism. Results showed that visual preferences to social stimuli strikingly differed between high-risk and low-risk newborns. Significant predictors for high-risk newborns were obtained and an accurate biomarker was identified. The results revealed early behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approach to the emergence of autism in early infancy.

AB - Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is usually not diagnosed until a child is at least 3 years old. Here, we circumvented this difficulty by studying for the very first time, the predispositions to pay attention to social stimuli in newborns with a high familial risk of autism. Results showed that visual preferences to social stimuli strikingly differed between high-risk and low-risk newborns. Significant predictors for high-risk newborns were obtained and an accurate biomarker was identified. The results revealed early behavioural characteristics of newborns with familial risk for ASD, allowing for a prospective approach to the emergence of autism in early infancy.

UR - http://www.scopus.com/inward/record.url?scp=84970028869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970028869&partnerID=8YFLogxK

U2 - 10.1038/srep26395

DO - 10.1038/srep26395

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 26395

ER -