Differences between conventional and nonconventional MRI techniques in Parkinson's disease

Annalisa Baglieri, Maria Adele Marino, Rosa Morabito, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino

Research output: Contribution to journalArticlepeer-review


Magnetic resonance imaging (MRI) provides an in vivo assessment of cortical and subcortical regions affected in Parkinson's disease (PD). This review summarizes the most important conventional and non-conventional MRI techniques applied in this field. Standard neuroimaging techniques have played a marginal role in the diagnosis and follow-up of PD, essentially being used only to discriminate atypical syndromes from PD, to exclude secondary causes such as vascular lesions, and to confirm the absence of specific imaging features found in atypical parkinsonisms. However, non-conventional MRI techniques, i.e. new neuroimaging approaches such as magnetic resonance spectroscopy, diffusion tensor imaging, and functional MRI, may allow the detection of structural, functional and metabolic changes useful not only for differential diagnosis, but also for early diagnosis and outcome and treatment monitoring in PD. In addition, we illustrate the advantages of high-field MRI over lower magnetic fields, highlighting the great potential of advanced neuroimaging techniques.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalFunctional Neurology
Issue number2
Publication statusPublished - 2013


  • Diffusion tensor imaging
  • Functional magnetic resonance imaging
  • High-field MRI
  • Magnetic resonance spectroscopy
  • Parkinson's disease
  • volumetric MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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