Abstract
We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P
Original language | English |
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Pages (from-to) | 873-880 |
Number of pages | 8 |
Journal | Bone Marrow Transplantation |
Volume | 32 |
Issue number | 9 |
DOIs | |
Publication status | Published - Nov 2003 |
Keywords
- Allogeneic hematopoietic stem cell transplantation
- Donor safety
- Granulocyte colony-stimulating factor
- Leukapheresis
- Peripheral blood stem cells
ASJC Scopus subject areas
- Hematology
- Transplantation