Differences between graft product and donor side effects following bone marrow or stem cell donation

G. Favre; M. Beksaç; A. Bacigalupo; T. Ruutu; A. Nagler; E. Gluckman; N. Russell; J. Apperley; J. Szer; K. Bradstock; A. Buzyn; J. Matcham; A. Gratwohl; N. Schmitz; H. Greinix; D. Niederwieser; D. Nachbauer; M. Boogaerts; A. Ferrant; R. Arnold; E. Gluckman; N. C. Gorin; N. Frickhofen; N. Schmitz; A. Zander; S. McCann; A. Nagler; A. Bacigalupo; A. Gratwohl; J. Apperley; N. H. Russell; O. Ringdén; I. Majolino; J. P. Jouet; B. Varet; J. Finke; G. Smith; A. Bosi; G. Lambertenghi-Deliliers; K. Kolbe; T. Ruutu; K. A. Bradstock; B. Lioure; T. Hughes; J. Szer; R. Herrmann; L. Trümper; M. Falda; M. Beksaç; E. Nikiforakis; M. Abecasis; J. Rowe; M. Potter; H. Wandt; R. Schwerdtfeger; J. Casper; A. Pagliuca

doi:10.1038/sj.bmt.1704245

Differences between graft product and donor side effects following bone marrow or stem cell donation

G. Favre, M. Beksaç, A. Bacigalupo, T. Ruutu, A. Nagler, E. Gluckman, N. Russell, J. Apperley, J. Szer, K. Bradstock, A. Buzyn, J. Matcham, A. Gratwohl, N. Schmitz, H. Greinix, D. Niederwieser, D. Nachbauer, M. Boogaerts, A. Ferrant, R. ArnoldE. Gluckman, N. C. Gorin, N. Frickhofen, N. Schmitz, A. Zander, S. McCann, A. Nagler, A. Bacigalupo, A. Gratwohl, J. Apperley, N. H. Russell, O. Ringdén, I. Majolino, J. P. Jouet, B. Varet, J. Finke, G. Smith, A. Bosi, G. Lambertenghi-Deliliers, K. Kolbe, T. Ruutu, K. A. Bradstock, B. Lioure, T. Hughes, J. Szer, R. Herrmann, L. Trümper, M. Falda, M. Beksaç, E. Nikiforakis, M. Abecasis, J. Rowe, M. Potter, H. Wandt, R. Schwerdtfeger, J. Casper, A. Pagliuca

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article

Abstract

We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34⁺ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34⁺ cells, 5.8 × 10⁶/kg vs 2.7 × 10⁶/kg; T cells, 300.1 × 10⁶/kg vs 35.7 × 10⁶/kg; NK cells, 28.2 × 10⁶/kg vs 3.6 × 10⁶ /kg; P

Original language	English
Pages (from-to)	873-880
Number of pages	8
Journal	Bone Marrow Transplantation
Volume	32
Issue number	9
DOIs	https://doi.org/10.1038/sj.bmt.1704245
Publication status	Published - Nov 2003

Keywords

Allogeneic hematopoietic stem cell transplantation
Donor safety
Granulocyte colony-stimulating factor
Leukapheresis
Peripheral blood stem cells

ASJC Scopus subject areas

Hematology
Transplantation

Access to Document

10.1038/sj.bmt.1704245

Fingerprint Dive into the research topics of 'Differences between graft product and donor side effects following bone marrow or stem cell donation'. Together they form a unique fingerprint.

Cite this

Favre, G., Beksaç, M., Bacigalupo, A., Ruutu, T., Nagler, A., Gluckman, E., Russell, N., Apperley, J., Szer, J., Bradstock, K., Buzyn, A., Matcham, J., Gratwohl, A., Schmitz, N., Greinix, H., Niederwieser, D., Nachbauer, D., Boogaerts, M., Ferrant, A., ... Pagliuca, A. (2003). Differences between graft product and donor side effects following bone marrow or stem cell donation. Bone Marrow Transplantation, 32(9), 873-880. https://doi.org/10.1038/sj.bmt.1704245

Differences between graft product and donor side effects following bone marrow or stem cell donation. / Favre, G.; Beksaç, M.; Bacigalupo, A.; Ruutu, T.; Nagler, A.; Gluckman, E.; Russell, N.; Apperley, J.; Szer, J.; Bradstock, K.; Buzyn, A.; Matcham, J.; Gratwohl, A.; Schmitz, N.; Greinix, H.; Niederwieser, D.; Nachbauer, D.; Boogaerts, M.; Ferrant, A.; Arnold, R.; Gluckman, E.; Gorin, N. C.; Frickhofen, N.; Schmitz, N.; Zander, A.; McCann, S.; Nagler, A.; Bacigalupo, A.; Gratwohl, A.; Apperley, J.; Russell, N. H.; Ringdén, O.; Majolino, I.; Jouet, J. P.; Varet, B.; Finke, J.; Smith, G.; Bosi, A.; Lambertenghi-Deliliers, G.; Kolbe, K.; Ruutu, T.; Bradstock, K. A.; Lioure, B.; Hughes, T.; Szer, J.; Herrmann, R.; Trümper, L.; Falda, M.; Beksaç, M.; Nikiforakis, E.; Abecasis, M.; Rowe, J.; Potter, M.; Wandt, H.; Schwerdtfeger, R.; Casper, J.; Pagliuca, A.

In: Bone Marrow Transplantation, Vol. 32, No. 9, 11.2003, p. 873-880.

Research output: Contribution to journal › Article

Favre, G, Beksaç, M, Bacigalupo, A, Ruutu, T, Nagler, A, Gluckman, E, Russell, N, Apperley, J, Szer, J, Bradstock, K, Buzyn, A, Matcham, J, Gratwohl, A, Schmitz, N, Greinix, H, Niederwieser, D, Nachbauer, D, Boogaerts, M, Ferrant, A, Arnold, R, Gluckman, E, Gorin, NC, Frickhofen, N, Schmitz, N, Zander, A, McCann, S, Nagler, A, Bacigalupo, A, Gratwohl, A, Apperley, J, Russell, NH, Ringdén, O, Majolino, I, Jouet, JP, Varet, B, Finke, J, Smith, G, Bosi, A, Lambertenghi-Deliliers, G, Kolbe, K, Ruutu, T, Bradstock, KA, Lioure, B, Hughes, T, Szer, J, Herrmann, R, Trümper, L, Falda, M, Beksaç, M, Nikiforakis, E, Abecasis, M, Rowe, J, Potter, M, Wandt, H, Schwerdtfeger, R, Casper, J & Pagliuca, A 2003, 'Differences between graft product and donor side effects following bone marrow or stem cell donation', Bone Marrow Transplantation, vol. 32, no. 9, pp. 873-880. https://doi.org/10.1038/sj.bmt.1704245

Favre, G. ; Beksaç, M. ; Bacigalupo, A. ; Ruutu, T. ; Nagler, A. ; Gluckman, E. ; Russell, N. ; Apperley, J. ; Szer, J. ; Bradstock, K. ; Buzyn, A. ; Matcham, J. ; Gratwohl, A. ; Schmitz, N. ; Greinix, H. ; Niederwieser, D. ; Nachbauer, D. ; Boogaerts, M. ; Ferrant, A. ; Arnold, R. ; Gluckman, E. ; Gorin, N. C. ; Frickhofen, N. ; Schmitz, N. ; Zander, A. ; McCann, S. ; Nagler, A. ; Bacigalupo, A. ; Gratwohl, A. ; Apperley, J. ; Russell, N. H. ; Ringdén, O. ; Majolino, I. ; Jouet, J. P. ; Varet, B. ; Finke, J. ; Smith, G. ; Bosi, A. ; Lambertenghi-Deliliers, G. ; Kolbe, K. ; Ruutu, T. ; Bradstock, K. A. ; Lioure, B. ; Hughes, T. ; Szer, J. ; Herrmann, R. ; Trümper, L. ; Falda, M. ; Beksaç, M. ; Nikiforakis, E. ; Abecasis, M. ; Rowe, J. ; Potter, M. ; Wandt, H. ; Schwerdtfeger, R. ; Casper, J. ; Pagliuca, A. / Differences between graft product and donor side effects following bone marrow or stem cell donation. In: Bone Marrow Transplantation. 2003 ; Vol. 32, No. 9. pp. 873-880.

@article{e0275a90d69548b88f9054f0be5aa4a7,

title = "Differences between graft product and donor side effects following bone marrow or stem cell donation",

abstract = "We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P",

keywords = "Allogeneic hematopoietic stem cell transplantation, Donor safety, Granulocyte colony-stimulating factor, Leukapheresis, Peripheral blood stem cells",

author = "G. Favre and M. Beksa{\c c} and A. Bacigalupo and T. Ruutu and A. Nagler and E. Gluckman and N. Russell and J. Apperley and J. Szer and K. Bradstock and A. Buzyn and J. Matcham and A. Gratwohl and N. Schmitz and H. Greinix and D. Niederwieser and D. Nachbauer and M. Boogaerts and A. Ferrant and R. Arnold and E. Gluckman and Gorin, {N. C.} and N. Frickhofen and N. Schmitz and A. Zander and S. McCann and A. Nagler and A. Bacigalupo and A. Gratwohl and J. Apperley and Russell, {N. H.} and O. Ringd{\'e}n and I. Majolino and Jouet, {J. P.} and B. Varet and J. Finke and G. Smith and A. Bosi and G. Lambertenghi-Deliliers and K. Kolbe and T. Ruutu and Bradstock, {K. A.} and B. Lioure and T. Hughes and J. Szer and R. Herrmann and L. Tr{\"u}mper and M. Falda and M. Beksa{\c c} and E. Nikiforakis and M. Abecasis and J. Rowe and M. Potter and H. Wandt and R. Schwerdtfeger and J. Casper and A. Pagliuca",

year = "2003",

month = nov,

doi = "10.1038/sj.bmt.1704245",

language = "English",

volume = "32",

pages = "873--880",

journal = "Bone Marrow Transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Differences between graft product and donor side effects following bone marrow or stem cell donation

AU - Favre, G.

AU - Beksaç, M.

AU - Bacigalupo, A.

AU - Ruutu, T.

AU - Nagler, A.

AU - Gluckman, E.

AU - Russell, N.

AU - Apperley, J.

AU - Szer, J.

AU - Bradstock, K.

AU - Buzyn, A.

AU - Matcham, J.

AU - Gratwohl, A.

AU - Schmitz, N.

AU - Greinix, H.

AU - Niederwieser, D.

AU - Nachbauer, D.

AU - Boogaerts, M.

AU - Ferrant, A.

AU - Arnold, R.

AU - Gluckman, E.

AU - Gorin, N. C.

AU - Frickhofen, N.

AU - Schmitz, N.

AU - Zander, A.

AU - McCann, S.

AU - Nagler, A.

AU - Bacigalupo, A.

AU - Gratwohl, A.

AU - Apperley, J.

AU - Russell, N. H.

AU - Ringdén, O.

AU - Majolino, I.

AU - Jouet, J. P.

AU - Varet, B.

AU - Finke, J.

AU - Smith, G.

AU - Bosi, A.

AU - Lambertenghi-Deliliers, G.

AU - Kolbe, K.

AU - Ruutu, T.

AU - Bradstock, K. A.

AU - Lioure, B.

AU - Hughes, T.

AU - Szer, J.

AU - Herrmann, R.

AU - Trümper, L.

AU - Falda, M.

AU - Beksaç, M.

AU - Nikiforakis, E.

AU - Abecasis, M.

AU - Rowe, J.

AU - Potter, M.

AU - Wandt, H.

AU - Schwerdtfeger, R.

AU - Casper, J.

AU - Pagliuca, A.

PY - 2003/11

Y1 - 2003/11

N2 - We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P

AB - We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P

KW - Allogeneic hematopoietic stem cell transplantation

KW - Donor safety

KW - Granulocyte colony-stimulating factor

KW - Leukapheresis

KW - Peripheral blood stem cells

UR - http://www.scopus.com/inward/record.url?scp=10744227378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744227378&partnerID=8YFLogxK

U2 - 10.1038/sj.bmt.1704245

DO - 10.1038/sj.bmt.1704245

M3 - Article

C2 - 14561987

AN - SCOPUS:10744227378

VL - 32

SP - 873

EP - 880

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 9

ER -