Differences between graft product and donor side effects following bone marrow or stem cell donation

G. Favre, M. Beksaç, A. Bacigalupo, T. Ruutu, A. Nagler, E. Gluckman, N. Russell, J. Apperley, J. Szer, K. Bradstock, A. Buzyn, J. Matcham, A. Gratwohl, N. Schmitz, H. Greinix, D. Niederwieser, D. Nachbauer, M. Boogaerts, A. Ferrant, R. ArnoldE. Gluckman, N. C. Gorin, N. Frickhofen, N. Schmitz, A. Zander, S. McCann, A. Nagler, A. Bacigalupo, A. Gratwohl, J. Apperley, N. H. Russell, O. Ringdén, I. Majolino, J. P. Jouet, B. Varet, J. Finke, G. Smith, A. Bosi, G. Lambertenghi-Deliliers, K. Kolbe, T. Ruutu, K. A. Bradstock, B. Lioure, T. Hughes, J. Szer, R. Herrmann, L. Trümper, M. Falda, M. Beksaç, E. Nikiforakis, M. Abecasis, J. Rowe, M. Potter, H. Wandt, R. Schwerdtfeger, J. Casper, A. Pagliuca

Research output: Contribution to journalArticle

Abstract

We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P

Original languageEnglish
Pages (from-to)873-880
Number of pages8
JournalBone Marrow Transplantation
Volume32
Issue number9
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Donor safety
  • Granulocyte colony-stimulating factor
  • Leukapheresis
  • Peripheral blood stem cells

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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  • Cite this

    Favre, G., Beksaç, M., Bacigalupo, A., Ruutu, T., Nagler, A., Gluckman, E., Russell, N., Apperley, J., Szer, J., Bradstock, K., Buzyn, A., Matcham, J., Gratwohl, A., Schmitz, N., Greinix, H., Niederwieser, D., Nachbauer, D., Boogaerts, M., Ferrant, A., ... Pagliuca, A. (2003). Differences between graft product and donor side effects following bone marrow or stem cell donation. Bone Marrow Transplantation, 32(9), 873-880. https://doi.org/10.1038/sj.bmt.1704245