Differences between graft product and donor side effects following bone marrow or stem cell donation

G. Favre; M. Beksaç; A. Bacigalupo; T. Ruutu; A. Nagler; E. Gluckman; N. Russell; J. Apperley; J. Szer; K. Bradstock; A. Buzyn; J. Matcham; A. Gratwohl; N. Schmitz; H. Greinix; D. Niederwieser; D. Nachbauer; M. Boogaerts; A. Ferrant; R. Arnold; E. Gluckman; N. C. Gorin; N. Frickhofen; N. Schmitz; A. Zander; S. McCann; A. Nagler; A. Bacigalupo; A. Gratwohl; J. Apperley; N. H. Russell; O. Ringdén; I. Majolino; J. P. Jouet; B. Varet; J. Finke; G. Smith; A. Bosi; G. Lambertenghi-Deliliers; K. Kolbe; T. Ruutu; K. A. Bradstock; B. Lioure; T. Hughes; J. Szer; R. Herrmann; L. Trümper; M. Falda; M. Beksaç; E. Nikiforakis; M. Abecasis; J. Rowe; M. Potter; H. Wandt; R. Schwerdtfeger; J. Casper; A. Pagliuca

doi:10.1038/sj.bmt.1704245

Differences between graft product and donor side effects following bone marrow or stem cell donation

G. Favre, M. Beksaç, A. Bacigalupo, T. Ruutu, A. Nagler, E. Gluckman, N. Russell, J. Apperley, J. Szer, K. Bradstock, A. Buzyn, J. Matcham, A. Gratwohl, N. Schmitz, H. Greinix, D. Niederwieser, D. Nachbauer, M. Boogaerts, A. Ferrant, R. ArnoldE. Gluckman, N. C. Gorin, N. Frickhofen, N. Schmitz, A. Zander, S. McCann, A. Nagler, A. Bacigalupo, A. Gratwohl, J. Apperley, N. H. Russell, O. Ringdén, I. Majolino, J. P. Jouet, B. Varet, J. Finke, G. Smith, A. Bosi, G. Lambertenghi-Deliliers, K. Kolbe, T. Ruutu, K. A. Bradstock, B. Lioure, T. Hughes, J. Szer, R. Herrmann, L. Trümper, M. Falda, M. Beksaç, E. Nikiforakis, M. Abecasis, J. Rowe, M. Potter, H. Wandt, R. Schwerdtfeger, J. Casper, A. Pagliuca

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34⁺ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34⁺ cells, 5.8 × 10⁶/kg vs 2.7 × 10⁶/kg; T cells, 300.1 × 10⁶/kg vs 35.7 × 10⁶/kg; NK cells, 28.2 × 10⁶/kg vs 3.6 × 10⁶ /kg; P

Original language	English
Pages (from-to)	873-880
Number of pages	8
Journal	Bone Marrow Transplantation
Volume	32
Issue number	9
DOIs	https://doi.org/10.1038/sj.bmt.1704245
Publication status	Published - Nov 2003

Keywords

Allogeneic hematopoietic stem cell transplantation
Donor safety
Granulocyte colony-stimulating factor
Leukapheresis
Peripheral blood stem cells

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1704245

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Favre, G., Beksaç, M., Bacigalupo, A., Ruutu, T., Nagler, A., Gluckman, E., Russell, N., Apperley, J., Szer, J., Bradstock, K., Buzyn, A., Matcham, J., Gratwohl, A., Schmitz, N., Greinix, H., Niederwieser, D., Nachbauer, D., Boogaerts, M., Ferrant, A., ... Pagliuca, A. (2003). Differences between graft product and donor side effects following bone marrow or stem cell donation. Bone Marrow Transplantation, 32(9), 873-880. https://doi.org/10.1038/sj.bmt.1704245

Differences between graft product and donor side effects following bone marrow or stem cell donation. / Favre, G.; Beksaç, M.; Bacigalupo, A.; Ruutu, T.; Nagler, A.; Gluckman, E.; Russell, N.; Apperley, J.; Szer, J.; Bradstock, K.; Buzyn, A.; Matcham, J.; Gratwohl, A.; Schmitz, N.; Greinix, H.; Niederwieser, D.; Nachbauer, D.; Boogaerts, M.; Ferrant, A.; Arnold, R.; Gluckman, E.; Gorin, N. C.; Frickhofen, N.; Schmitz, N.; Zander, A.; McCann, S.; Nagler, A.; Bacigalupo, A.; Gratwohl, A.; Apperley, J.; Russell, N. H.; Ringdén, O.; Majolino, I.; Jouet, J. P.; Varet, B.; Finke, J.; Smith, G.; Bosi, A.; Lambertenghi-Deliliers, G.; Kolbe, K.; Ruutu, T.; Bradstock, K. A.; Lioure, B.; Hughes, T.; Szer, J.; Herrmann, R.; Trümper, L.; Falda, M.; Beksaç, M.; Nikiforakis, E.; Abecasis, M.; Rowe, J.; Potter, M.; Wandt, H.; Schwerdtfeger, R.; Casper, J.; Pagliuca, A.

In: Bone Marrow Transplantation, Vol. 32, No. 9, 11.2003, p. 873-880.

Research output: Contribution to journal › Article › peer-review

Favre, G, Beksaç, M, Bacigalupo, A, Ruutu, T, Nagler, A, Gluckman, E, Russell, N, Apperley, J, Szer, J, Bradstock, K, Buzyn, A, Matcham, J, Gratwohl, A, Schmitz, N, Greinix, H, Niederwieser, D, Nachbauer, D, Boogaerts, M, Ferrant, A, Arnold, R, Gluckman, E, Gorin, NC, Frickhofen, N, Schmitz, N, Zander, A, McCann, S, Nagler, A, Bacigalupo, A, Gratwohl, A, Apperley, J, Russell, NH, Ringdén, O, Majolino, I, Jouet, JP, Varet, B, Finke, J, Smith, G, Bosi, A, Lambertenghi-Deliliers, G, Kolbe, K, Ruutu, T, Bradstock, KA, Lioure, B, Hughes, T, Szer, J, Herrmann, R, Trümper, L, Falda, M, Beksaç, M, Nikiforakis, E, Abecasis, M, Rowe, J, Potter, M, Wandt, H, Schwerdtfeger, R, Casper, J & Pagliuca, A 2003, 'Differences between graft product and donor side effects following bone marrow or stem cell donation', Bone Marrow Transplantation, vol. 32, no. 9, pp. 873-880. https://doi.org/10.1038/sj.bmt.1704245

Favre, G. ; Beksaç, M. ; Bacigalupo, A. ; Ruutu, T. ; Nagler, A. ; Gluckman, E. ; Russell, N. ; Apperley, J. ; Szer, J. ; Bradstock, K. ; Buzyn, A. ; Matcham, J. ; Gratwohl, A. ; Schmitz, N. ; Greinix, H. ; Niederwieser, D. ; Nachbauer, D. ; Boogaerts, M. ; Ferrant, A. ; Arnold, R. ; Gluckman, E. ; Gorin, N. C. ; Frickhofen, N. ; Schmitz, N. ; Zander, A. ; McCann, S. ; Nagler, A. ; Bacigalupo, A. ; Gratwohl, A. ; Apperley, J. ; Russell, N. H. ; Ringdén, O. ; Majolino, I. ; Jouet, J. P. ; Varet, B. ; Finke, J. ; Smith, G. ; Bosi, A. ; Lambertenghi-Deliliers, G. ; Kolbe, K. ; Ruutu, T. ; Bradstock, K. A. ; Lioure, B. ; Hughes, T. ; Szer, J. ; Herrmann, R. ; Trümper, L. ; Falda, M. ; Beksaç, M. ; Nikiforakis, E. ; Abecasis, M. ; Rowe, J. ; Potter, M. ; Wandt, H. ; Schwerdtfeger, R. ; Casper, J. ; Pagliuca, A. / Differences between graft product and donor side effects following bone marrow or stem cell donation. In: Bone Marrow Transplantation. 2003 ; Vol. 32, No. 9. pp. 873-880.

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abstract = "We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM transplantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34+ cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34+ cells, 5.8 × 106/kg vs 2.7 × 106/kg; T cells, 300.1 × 106/kg vs 35.7 × 106/kg; NK cells, 28.2 × 106/kg vs 3.6 × 106 /kg; P",

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AU - Nagler, A.

AU - Gluckman, E.

AU - Russell, N.

AU - Apperley, J.

AU - Szer, J.

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AU - Buzyn, A.

AU - Matcham, J.

AU - Gratwohl, A.

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AU - Schmitz, N.

AU - Zander, A.

AU - McCann, S.

AU - Nagler, A.

AU - Bacigalupo, A.

AU - Gratwohl, A.

AU - Apperley, J.

AU - Russell, N. H.

AU - Ringdén, O.

AU - Majolino, I.

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AU - Nikiforakis, E.

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AU - Rowe, J.

AU - Potter, M.

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Differences between graft product and donor side effects following bone marrow or stem cell donation

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