Differences between patients', physicians' and pharmacists' preferences for treatment products in haemophilia: A discrete choice experiment

Lorenzo G. Mantovani, M. S. Monzini, P. M. Mannucci, L. Scalone, M. Villa, A. Gringeri, Giovanni Barillari, Francesco Baudo, Atto Billio, Luisa Bizzoni, Elio Boeri, Biagio Caputo, Giancarlo Castaman, Laura Contino, Grazia Delios, Antonio Coppola, Alfredo Dragani, Giulio Feola, Daniela Bertuzzo, Marco D'IncàElena Santagostino, PierGiorgio Iannaccaro, Alfonso Iorio, Giacomo Mancuso, Massimo Morfini, Roberto Musso, Gavino Piseddu, Angiola Rocino, Giuseppina Rodorigo, Gina Rossetti, Francesco Antonio Scaraggi, Mario Schiavoni, PierCarla Schinco, Giuseppe Tagariello, Annarita Tagliaferri, Roberto Targhetta, Vincenzo Trapani Lombardo, Ezio Zanon

Research output: Contribution to journalArticlepeer-review

Abstract

The provision of health care to patients with haemophilia through replacement of the deficient coagulation factor is the result of a complex interaction between patients, physicians and policy makers, each carrying their individual sets of preferences. Preferences of patients, physicians and pharmacists towards perceived viral safety, risk of inhibitor development, infusion frequency during prophylaxis, pharmaceutical dosage form, distribution modes and price were evaluated by conjoint analysis, using a discrete choice experiment. Overall 178 patients', 69 physicians and 58 pharmacists completed the study. Patients, physicians and pharmacists displayed preferences: (i) similar in direction and strength for risk of inhibitors and frequency of prophylaxis, (ii) similar in direction, but not in strength for perceived viral safety and price, with patients showing lower strength compared with physicians and pharmacists, and (iii) dissimilar in direction and/or strength for: (i) dosage form, which tested important only for pharmacists and (ii) distribution mode, which tested important for patients and physicians only. Our study provides evidence of the differences between different stakeholders in the preferences towards haemophilia replacement therapy, indicating that different opinions should be taken into account when planning optimal care.

Original languageEnglish
Pages (from-to)589-597
Number of pages9
JournalHaemophilia
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Coagulation factor concentrates
  • Conjoint analysis
  • Discrete choice experiment
  • Haemophilia
  • Inhibitor
  • Preferences

ASJC Scopus subject areas

  • Hematology

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