Differences in duration of untreated illness, duration, and severity of illness among clinical phenotypes of obsessive-compulsive disorder

Bernardo Dell'Osso, Beatrice Benatti, Lucio Oldani, Gregorio Spagnolin, A. Carlo Altamura

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Obsessive-compulsive disorder (OCD) is a prevalent, disabling, and comorbid condition that is frequently under-recognized and poorly treated. OCD phenotypes may differ in terms of clinical presentation and severity. However, few studies have investigated whether clinical phenotypes differ in terms of latency to treatment (ie, duration of untreated illness[DUI]), duration, and severity of illness. The present study was aimed to quantify the aforementioned variables in a sample of OCD patients. Methods One hundred fourteen outpatients with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of OCD were recruited, and their main clinical features were collected. Severity of illness was assessed through the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and the main phenotypes were identified through the Y-BOCS Symptom Checklist. A one-way analysis of variance (ANOVA) test, followed by a Bonferroni post-hoc test, were performed to compare DUI, duration, and severity of illness across subgroups. Results In the whole sample, the mean DUI exceeded 7 years (87.35±11.75 months), accounting for approximately half of the mean duration of illness (172.2±13.36 months). When subjects were categorized into 4 main clinical phenotypes, respectively, aggressive/checking (n=31), contamination/cleaning (n=37), symmetry/ordering (n=32), and multiple phenotypes (n=14), DUI, duration, and severity of illness resulted significantly higher in the aggressive/checking subgroup, compared to other subgroups (F=3.58, p

Original languageEnglish
Pages (from-to)474-478
Number of pages5
JournalCNS Spectrums
Volume20
Issue number5
DOIs
Publication statusPublished - Jun 26 2014

Keywords

  • duration of untreated illness
  • Obsessive compulsive disorder
  • obsessive compulsive disorder clinical phenotypes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Medicine(all)

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