Differences in frequency distribution of HLA-A2 subtypes between North American and Italian white melanoma patients: Relevance for epitope specific vaccination protocols

Mary Anne Player, Kathleen C. Barracchini, Toni B. Simonis, Licia Rivoltini, Flavio Arienti, Chiara Castelli, Arabella Mazzocchi, Filiberto Belli, Giorgio Parmiani, Francesco M. Marincola

Research output: Contribution to journalArticlepeer-review

Abstract

Cytotoxic T lymphocytes (CTL) associated in vivo with tumor regression recognize the product of nonmutated genes expressed by most melanoma cells as peptides bound to human leukocyte antigen (HLA) molecules. Multiple HLA- A*0201 restricted peptides derived from melanoma associated antigens (MAA) have been described, and peptide-based vaccination protocols against melanoma are being developed worldwide for the treatment of HLA-A2 melanoma patients based on the assumption that most serologically typed HLA-A2+ individuals will be suitable for such vaccinations. Serologic typing of HLA-A2, however, encompasses a family of at least 17 related alleles recognized by molecular typing techniques and differing at one or more functional residues of the HLA class I molecule. We have recently shown that naturally occurring single residue variants of HLA-A*0201 are responsible for significant differences in CTL response to MAA-peptide stimulation. Existing data for HLA-A*02 subtype frequencies among whites (who are most affected by melanoma) derive from analyses of Northern European and North American populations that are of similar heritage and predict an exceedingly rare (2 value = 0.001). As allele-specific/peptide-based vaccination protocols are presently pursued at several institutions, a proportion of patients might be inappropriately enrolled basing their eligibility on serologically defined HLA-typing.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalJournal of Immunotherapy
Volume19
Issue number5
Publication statusPublished - 1996

Keywords

  • HLA
  • Melanoma
  • Melanoma antigens

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Immunology

Fingerprint

Dive into the research topics of 'Differences in frequency distribution of HLA-A2 subtypes between North American and Italian white melanoma patients: Relevance for epitope specific vaccination protocols'. Together they form a unique fingerprint.

Cite this