Differences in gene expression in the hippocampus of aged rats are associated with better long-term memory performance in a passive avoidance test

Giuseppina Di Stefano, Tiziana Casoli, Daniela Platano, Patrizia Fattoretti, Marta Balietti, Belinda Giorgetti, Carlo Bertoni-Freddari, Fabrizia Lattanzio, Giorgio Aicardi

Research output: Contribution to journalArticle

Abstract

Microarray analysis was used to identify genes differentially expressed in the hippocampus of aged rats showing diverse long-term (3 and 6h) spatial-associative memory performance in a single-trial inhibitory avoidance task. The transcription of 43 genes (including genes functionally linked to signal transduction, cell growth and differentiation, translation, energy metabolism, and nucleic acid processing) was significantly upregulated in good-versus bad-performing animals, whereas that of 18 genes (including genes functionally linked to transcription, cell growth and differentiation, apoptosis, and protein transport) was significantly downregulated in good-versus bad-performing animals. The differential expression of 14 of these genes was confirmed by real-time polymerase chain reaction.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalRejuvenation Research
Volume13
Issue number2-3
DOIs
Publication statusPublished - Apr 1 2010

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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