TY - JOUR
T1 - Differences in heart rate turbulence between patients with coronary artery disease and patients with ventricular arrhythmias but structurally normal hearts
AU - Sestito, Alfonso
AU - Valsecchi, Sergio
AU - Infusino, Fabio
AU - Sgueglia, Gregory Angelo
AU - Bellocci, Fulvio
AU - Zecchi, Paolo
AU - Crea, Filippo
AU - Lanza, Gaetano Antonio
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The term "heart rate turbulence" (HRT) indicates the physiologic changes in the sinus cycle that follow a ventricular premature complex; impaired HRT denotes abnormalities in cardiac autonomic function. To investigate whether HRT is impaired in patients with stable coronary artery disease (CAD), we studied 29 patients with documented CAD and frequent (≥30/hour) ventricular premature complexes on Holter monitoring and 31 patients with frequent ventricular arrhythmias but normal hearts (NH-VA). HRT and heart rate variability analyses were analyzed on 24-hour Holter recordings. HRT variables differed significantly between the 2 groups (turbulence onset -0.20 ± 1.7% vs -0.67 ± 2.2%, p = 0.00001; turbulence slope 2.83 ± 1.9 vs 10.83 ± 7.4 ms/RR, p = 0.0001 in patients with CAD and NH-VA, respectively). The difference was independent of a history of previous myocardial infarction, left ventricular function, and age. Top quartile turbulence onset values (>-0.26%) and bottom quartile turbulence slope values (
AB - The term "heart rate turbulence" (HRT) indicates the physiologic changes in the sinus cycle that follow a ventricular premature complex; impaired HRT denotes abnormalities in cardiac autonomic function. To investigate whether HRT is impaired in patients with stable coronary artery disease (CAD), we studied 29 patients with documented CAD and frequent (≥30/hour) ventricular premature complexes on Holter monitoring and 31 patients with frequent ventricular arrhythmias but normal hearts (NH-VA). HRT and heart rate variability analyses were analyzed on 24-hour Holter recordings. HRT variables differed significantly between the 2 groups (turbulence onset -0.20 ± 1.7% vs -0.67 ± 2.2%, p = 0.00001; turbulence slope 2.83 ± 1.9 vs 10.83 ± 7.4 ms/RR, p = 0.0001 in patients with CAD and NH-VA, respectively). The difference was independent of a history of previous myocardial infarction, left ventricular function, and age. Top quartile turbulence onset values (>-0.26%) and bottom quartile turbulence slope values (
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U2 - 10.1016/j.amjcard.2004.01.037
DO - 10.1016/j.amjcard.2004.01.037
M3 - Article
C2 - 15110202
AN - SCOPUS:1942436144
VL - 93
SP - 1114
EP - 1118
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 9
ER -