Differences in lipopolysaccharide-induced signaling between conventional dendritic cells and macrophages

Ivan Zanoni, Francesca Granucci

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) and macrophages contribute to the activation of immune responses against infectious agents. They sense the presence of microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize pathogen-associated molecular patterns (PAMPs). Among the different PAMPs, the response to lipopolysaccharide (LPS) is one of the best characterized. Upon LPS encounter DCs undergo an activation process and acquire the ability to prime both natural killer and T-cell responses after migration to lymph nodes. Once they completed the effector phase, DCs reach a terminal differentiation stage and eventually die by apoptosis. By contrast, macrophages do not leave the tissue upon LPS recognition. They first initiate inflammatory processes and then switch to an anti-inflammatory phenotype to restore tissue homeostasis. In this review we will focus on the molecular bases of the divergent responses of DCs and macrophages to LPS.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalImmunobiology
Volume215
Issue number9-10
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Apoptosis
  • CD14
  • Dendritic cells
  • Innate immunity
  • Macrophages
  • Toll like receptors

ASJC Scopus subject areas

  • Immunology
  • Hematology
  • Immunology and Allergy

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