Differences in Progression to Obstructive Lesions per High-Risk Plaque Features and Plaque Volumes With CCTA

Sang-Eun Lee, Ji Min Sung, Daniele Andreini, Mouaz H Al-Mallah, Matthew J Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Eun Ju Chun, Edoardo Conte, Ilan Gottlieb, Martin Hadamitzky, Yong Jin Kim, Byoung Kwon Lee, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Gianluca Pontone, Gilbert L RaffSanghoon Shin, Peter H Stone, Habib Samady, Renu Virmani, Jagat Narula, Daniel S Berman, Leslee J Shaw, Jeroen J Bax, Fay Y Lin, James K Min, Hyuk-Jae Chang

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: This study explored whether the pattern of nonobstructive lesion progression into obstructive lesions would differ according to the presence of high-risk plaque (HRP).BACKGROUND: It is still debatable whether HRP simply represents a certain phase during the natural history of coronary atherosclerotic plaques or if disease progression would differ according to the presence of HRP.METHODS: Patients with nonobstructive coronary artery disease, defined as percent diameter stenosis (%DS) 0.05).CONCLUSIONS: The pattern of individual coronary atherosclerotic plaque progression differed according to the presence of HRP. Baseline PAV, not the presence of HRP features, was the most important predictor of lesions developing into obstructive lesions. (Progression of Atherosclerotic Plaque Determined By Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411).
Original languageEnglish
JournalJACC: Cardiovascular Imaging
DOIs
Publication statusPublished - Nov 13 2019

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    Lee, S-E., Sung, J. M., Andreini, D., Al-Mallah, M. H., Budoff, M. J., Cademartiri, F., Chinnaiyan, K., Choi, J. H., Chun, E. J., Conte, E., Gottlieb, I., Hadamitzky, M., Kim, Y. J., Lee, B. K., Leipsic, J. A., Maffei, E., Marques, H., de Araújo Gonçalves, P., Pontone, G., ... Chang, H-J. (2019). Differences in Progression to Obstructive Lesions per High-Risk Plaque Features and Plaque Volumes With CCTA. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2019.09.011