Differences in short-term primary motor cortex synaptic potentiation as assessed by repetitive transcranial magnetic stimulation in migraine patients with and without aura

Antonella Conte, Piero Barbanti, Vittorio Frasca, Elisa Iacovelli, Maria Gabriele, Elena Giacomelli, Cinzia Aurilia, Floriana Pichiorri, Francesca Gilio, Maurizio Inghilleri

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

To find out more about glutamatergic and gabaergic transmission in migraine, in this study we investigated glutamate-dependent short-term synaptic potentiation and GABA-dependent inhibitory cortical interneuron excitability as assessed by 5 Hz-rTMS delivered over primary motor cortex (M1) (motor evoked potential, MEP, amplitude facilitation and cortical silent period, CSP, duration lengthening) in migraine patients with (MA) and without aura (MwoA) and healthy controls. We studied 37 patients with migraine (19 MA and 18 MwoA) and 19 healthy control subjects. 5 Hz-rTMS was delivered at 120% resting motor threshold to the hand motor area of the left hemisphere with the target muscle at rest and during contraction. Three of the MA patients were also tested at the end of visual aura during a spontaneous migraine attack. ANOVA showed that the MEP significantly increased in size and CSP significantly lengthened during 5 Hz-rTMS in the three groups tested. The 5 Hz-rTMS-induced MEP facilitation differed significantly being highest in MA patients. In the three patients tested both ictally and interictally the MEP increased during the interictal session but remained unchanged when the visual aura ended. Our study shows that the neurophysiological feature that differentiates MA patients from MwoA patients and healthy controls is an abnormal M1 susceptibility to 5 Hz-rTMS both outside and during the attack suggesting that glutamate-dependent short-term M1 cortical potentiation patterns differ in migraine with and without aura.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalPain
Volume148
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Migraine without Aura
Migraine with Aura
Transcranial Magnetic Stimulation
Motor Cortex
Epilepsy
Migraine Disorders
Glutamic Acid
Motor Evoked Potentials
Interneurons
gamma-Aminobutyric Acid
Analysis of Variance
Healthy Volunteers
Hand
Muscles

Keywords

  • Migraine
  • Migraine aura
  • rTMS
  • Short-term plasticity

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Differences in short-term primary motor cortex synaptic potentiation as assessed by repetitive transcranial magnetic stimulation in migraine patients with and without aura. / Conte, Antonella; Barbanti, Piero; Frasca, Vittorio; Iacovelli, Elisa; Gabriele, Maria; Giacomelli, Elena; Aurilia, Cinzia; Pichiorri, Floriana; Gilio, Francesca; Inghilleri, Maurizio.

In: Pain, Vol. 148, No. 1, 01.2010, p. 43-48.

Research output: Contribution to journalArticle

Conte, Antonella ; Barbanti, Piero ; Frasca, Vittorio ; Iacovelli, Elisa ; Gabriele, Maria ; Giacomelli, Elena ; Aurilia, Cinzia ; Pichiorri, Floriana ; Gilio, Francesca ; Inghilleri, Maurizio. / Differences in short-term primary motor cortex synaptic potentiation as assessed by repetitive transcranial magnetic stimulation in migraine patients with and without aura. In: Pain. 2010 ; Vol. 148, No. 1. pp. 43-48.
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