Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalCarcinogenesis
Volume2
Issue number3
Publication statusPublished - 1981

Fingerprint

Sister Chromatid Exchange
Cyclophosphamide
Bone Marrow Cells
Body Weight
Injections

ASJC Scopus subject areas

  • Cancer Research

Cite this

Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains. / Dragani, T. A.; Zunino, A.; Sozzi, G.

In: Carcinogenesis, Vol. 2, No. 3, 1981, p. 219-222.

Research output: Contribution to journalArticle

@article{2ce5248c514e4d07a503b4093f216005,
title = "Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains",
abstract = "The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.",
author = "Dragani, {T. A.} and A. Zunino and G. Sozzi",
year = "1981",
language = "English",
volume = "2",
pages = "219--222",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains

AU - Dragani, T. A.

AU - Zunino, A.

AU - Sozzi, G.

PY - 1981

Y1 - 1981

N2 - The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.

AB - The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.

UR - http://www.scopus.com/inward/record.url?scp=0019829888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019829888&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 219

EP - 222

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 3

ER -