Abstract
The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.
| Original language | English |
|---|---|
| Pages (from-to) | 219-222 |
| Number of pages | 4 |
| Journal | Carcinogenesis |
| Volume | 2 |
| Issue number | 3 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Cancer Research
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Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains. / Dragani, T. A.; Zunino, A.; Sozzi, G.
In: Carcinogenesis, Vol. 2, No. 3, 1981, p. 219-222.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differences in sister chromatid exchange (SCE)-induction in vivo by cyclophosphamide in murine strains
AU - Dragani, T. A.
AU - Zunino, A.
AU - Sozzi, G.
PY - 1981
Y1 - 1981
N2 - The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.
AB - The susceptibility to sister chromatid exchange (SCE)-induction in bone marrow cells by cyclophosphamide (CPA) was tested in DBA/2, AKR, C57BL/6J, C3Hf and BALB/c mice in vivo. Mice were treated with one i.p. injection of 0.4, 2.0 and 10.0 mg/kg body weight of CPA or of saline. The base-line level of SCE was similar in all the strains, with about 3 SCE/cell. Increasing concentrations of CPA caused an increased level of SCE. At any dose level, differences in the SCE frequency were observed among the five strains. The greatest difference was seen at the dose of 10 mg/kg, when the DBA/2 strain reached the frequency of 25.5 SCE/cell, whereas 19.3, 12.9, 11.4 and 10.1 SCE/cell were seen respectively in AKR, C57BL/6J, C3Hf and BALB/c mice.
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M3 - Article
VL - 2
SP - 219
EP - 222
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 3
ER -