Differences in subependymal vein anatomy may predispose preterm infants to GMH-IVH

Domenico Tortora, Mariasavina Severino, Mariya Malova, Alessandro Parodi, Giovanni Morana, Jan Sedlacik, Paul Govaert, Joseph J Volpe, Andrea Rossi, Luca Antonio Ramenghi

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE: The anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH-IVH.

METHODS: SWI venographies of 48 neonates with GMH-IVH and 130 neonates with normal brain MRI were retrospectively evaluated. Subependymal vein anatomy was classified into six different patterns: type 1 represented the classic pattern and types 2-6 were considered anatomic variants. A quantitative analysis of the venous curvature index was performed. Variables were analysed by using Mann-Whitney U and χ2 tests, and a multiple logistic regression analysis was performed to evaluate the association between anatomical features, clinical factors and GMH-IVH.

RESULTS: A significant difference was noticed among the six anatomical patterns according to the presence of GMH-IVH (χ2=14.242, p=0.014). Anatomic variants were observed with higher frequency in neonates with GMH-IVH than in controls (62.2% and 49.6%, respectively). Neonates with GMH-IVH presented a narrower curvature of the terminal portion of subependymal veins (p<0.05). These anatomical features were significantly associated with GMH-IVH (p<0.05).

CONCLUSION: Preterm neonates with GMH-IVH show higher variability of subependymal veins anatomy confirming a potential role as predisposing factor for GMH-IVH.

Original languageEnglish
Pages (from-to)F59-F65
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Volume103
Issue number1
DOIs
Publication statusPublished - Jan 2018

Fingerprint

Premature Infants
Veins
Anatomy
Hemorrhage
Newborn Infant
Phlebography
Brain
Nonparametric Statistics

Keywords

  • Analysis of Variance
  • Anatomy, Regional/methods
  • Causality
  • Cerebral Intraventricular Hemorrhage/diagnosis
  • Cerebral Veins/anatomy & histology
  • Cerebral Ventricles/blood supply
  • Female
  • Functional Neuroimaging/methods
  • Humans
  • Infant, Newborn
  • Infant, Premature/physiology
  • Magnetic Resonance Angiography/methods
  • Male
  • Phlebography/methods
  • Risk Assessment

Cite this

@article{0b26be4e83e641dbabf739a9ea2000d0,
title = "Differences in subependymal vein anatomy may predispose preterm infants to GMH-IVH",
abstract = "BACKGROUND AND PURPOSE: The anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH-IVH.METHODS: SWI venographies of 48 neonates with GMH-IVH and 130 neonates with normal brain MRI were retrospectively evaluated. Subependymal vein anatomy was classified into six different patterns: type 1 represented the classic pattern and types 2-6 were considered anatomic variants. A quantitative analysis of the venous curvature index was performed. Variables were analysed by using Mann-Whitney U and χ2 tests, and a multiple logistic regression analysis was performed to evaluate the association between anatomical features, clinical factors and GMH-IVH.RESULTS: A significant difference was noticed among the six anatomical patterns according to the presence of GMH-IVH (χ2=14.242, p=0.014). Anatomic variants were observed with higher frequency in neonates with GMH-IVH than in controls (62.2{\%} and 49.6{\%}, respectively). Neonates with GMH-IVH presented a narrower curvature of the terminal portion of subependymal veins (p<0.05). These anatomical features were significantly associated with GMH-IVH (p<0.05).CONCLUSION: Preterm neonates with GMH-IVH show higher variability of subependymal veins anatomy confirming a potential role as predisposing factor for GMH-IVH.",
keywords = "Analysis of Variance, Anatomy, Regional/methods, Causality, Cerebral Intraventricular Hemorrhage/diagnosis, Cerebral Veins/anatomy & histology, Cerebral Ventricles/blood supply, Female, Functional Neuroimaging/methods, Humans, Infant, Newborn, Infant, Premature/physiology, Magnetic Resonance Angiography/methods, Male, Phlebography/methods, Risk Assessment",
author = "Domenico Tortora and Mariasavina Severino and Mariya Malova and Alessandro Parodi and Giovanni Morana and Jan Sedlacik and Paul Govaert and Volpe, {Joseph J} and Andrea Rossi and Ramenghi, {Luca Antonio}",
note = "{\circledC} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2018",
month = "1",
doi = "10.1136/archdischild-2017-312710",
language = "English",
volume = "103",
pages = "F59--F65",
journal = "Archives of Disease in Childhood: Fetal and Neonatal Edition",
issn = "1359-2998",
publisher = "BMJ Publishing Group",
number = "1",

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TY - JOUR

T1 - Differences in subependymal vein anatomy may predispose preterm infants to GMH-IVH

AU - Tortora, Domenico

AU - Severino, Mariasavina

AU - Malova, Mariya

AU - Parodi, Alessandro

AU - Morana, Giovanni

AU - Sedlacik, Jan

AU - Govaert, Paul

AU - Volpe, Joseph J

AU - Rossi, Andrea

AU - Ramenghi, Luca Antonio

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/1

Y1 - 2018/1

N2 - BACKGROUND AND PURPOSE: The anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH-IVH.METHODS: SWI venographies of 48 neonates with GMH-IVH and 130 neonates with normal brain MRI were retrospectively evaluated. Subependymal vein anatomy was classified into six different patterns: type 1 represented the classic pattern and types 2-6 were considered anatomic variants. A quantitative analysis of the venous curvature index was performed. Variables were analysed by using Mann-Whitney U and χ2 tests, and a multiple logistic regression analysis was performed to evaluate the association between anatomical features, clinical factors and GMH-IVH.RESULTS: A significant difference was noticed among the six anatomical patterns according to the presence of GMH-IVH (χ2=14.242, p=0.014). Anatomic variants were observed with higher frequency in neonates with GMH-IVH than in controls (62.2% and 49.6%, respectively). Neonates with GMH-IVH presented a narrower curvature of the terminal portion of subependymal veins (p<0.05). These anatomical features were significantly associated with GMH-IVH (p<0.05).CONCLUSION: Preterm neonates with GMH-IVH show higher variability of subependymal veins anatomy confirming a potential role as predisposing factor for GMH-IVH.

AB - BACKGROUND AND PURPOSE: The anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH-IVH.METHODS: SWI venographies of 48 neonates with GMH-IVH and 130 neonates with normal brain MRI were retrospectively evaluated. Subependymal vein anatomy was classified into six different patterns: type 1 represented the classic pattern and types 2-6 were considered anatomic variants. A quantitative analysis of the venous curvature index was performed. Variables were analysed by using Mann-Whitney U and χ2 tests, and a multiple logistic regression analysis was performed to evaluate the association between anatomical features, clinical factors and GMH-IVH.RESULTS: A significant difference was noticed among the six anatomical patterns according to the presence of GMH-IVH (χ2=14.242, p=0.014). Anatomic variants were observed with higher frequency in neonates with GMH-IVH than in controls (62.2% and 49.6%, respectively). Neonates with GMH-IVH presented a narrower curvature of the terminal portion of subependymal veins (p<0.05). These anatomical features were significantly associated with GMH-IVH (p<0.05).CONCLUSION: Preterm neonates with GMH-IVH show higher variability of subependymal veins anatomy confirming a potential role as predisposing factor for GMH-IVH.

KW - Analysis of Variance

KW - Anatomy, Regional/methods

KW - Causality

KW - Cerebral Intraventricular Hemorrhage/diagnosis

KW - Cerebral Veins/anatomy & histology

KW - Cerebral Ventricles/blood supply

KW - Female

KW - Functional Neuroimaging/methods

KW - Humans

KW - Infant, Newborn

KW - Infant, Premature/physiology

KW - Magnetic Resonance Angiography/methods

KW - Male

KW - Phlebography/methods

KW - Risk Assessment

U2 - 10.1136/archdischild-2017-312710

DO - 10.1136/archdischild-2017-312710

M3 - Article

VL - 103

SP - F59-F65

JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

SN - 1359-2998

IS - 1

ER -