Differences in the effect of the antidepressant amineptine on striatal and limbic DOPAC measured by HPLC-ECD and in vivo voltammetry

Maria Grazia De Simoni, Giuseppe Dal Toso, Sergio Algeri, Franca Ponzio

Research output: Contribution to journalArticle

Abstract

The acute effect of the antidepressant amineptine was studied in two dopaminergic areas, the striatum and the limbic system, by in vivo voltammetry. This electrochemical technique uses carbon fibre electrodes implanted in brain areas of non-anaesthetized freely moving rats to measure DOPAC diffusing from the neurons. In vivo voltammetry recordings showed that amineptine induced a slight and transient decrease in DOPAC levels in the caudate nucleus but a persistent, clear-cut decrease in the nucleus accumbens. These results were confirmed by classical biochemical determination in tissue samples. The findings indicate the possible importance of the limbic area in the mechanism of action of amineptine.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalEuropean Journal of Pharmacology
Volume123
Issue number3
DOIs
Publication statusPublished - Apr 29 1986

Keywords

  • Amineptine
  • DOPAC
  • HPLC-ECD
  • In vivo voltammetry
  • Mesolimbic system
  • Striatum

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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