Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: Comparison to other interferons

Maria R. Capobianchi, Franco Ameglio, Roberto Tosi, Antonina Dolei

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as follows: class II molecules are markedly increased by IFN gamma; IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect. Kinetically, the action of IFN gamma is prompter and longer lasting than that of IFN beta. DQ expression is much more enhanced by IFN gamma than either DR or BR; IFN beta has the same effect on all three subsets. Parallel changes of the cellular expression and of the shedding of these molecules are observed. A melanoma and a lymphoblastoid cell line and peripheral blood mononuclear cells show qualitatively similar modifications.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalHuman Immunology
Volume13
Issue number1
DOIs
Publication statusPublished - 1985

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Interferon-beta
Interferons
Interferon-gamma
Interferon-alpha
Melanoma
Blood Cells
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma : Comparison to other interferons. / Capobianchi, Maria R.; Ameglio, Franco; Tosi, Roberto; Dolei, Antonina.

In: Human Immunology, Vol. 13, No. 1, 1985, p. 1-11.

Research output: Contribution to journalArticle

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