Differences In the Gene Expression Profile of Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases

Bernhard Gentner, Axel Wein, Roland S. Croner, Isabel Zeittraeger, Ralph M. Wirtz, Franz Roedel, Arno Dimmler, Laure Dorlaque, Werner Hohenberger, Eckhart G. Hahn, Wolfgang M. Brueckl

Research output: Contribution to journalArticle

Abstract

Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been strongly implicated in the pathogenesis of many types of human cancer. We wanted to specifically define their role in established colorectal cancer liver metastases. Patients and Methods: The MMP/TIMP expression profiles of N=9 colorectal primary tumour liver metastasis tissue pairs were determined using oligonucleotide-based arrays. Expression levels for the most relevant MMPs were confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR). Additionally, unsupervised clustering using the MMP/TIMP profile of N=25 colorectal cancer liver metastases was performed and the response to palliative 5-fluorouracil (5-FU)-based chemotherapy was assessed using radiological response criteria. Results: When comparing the primary tumors to their synchronous liver metastases, a statistically significant (p

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalAnticancer Research
Volume29
Issue number1
Publication statusPublished - Jan 2009

Keywords

  • Colorectal carcinoma (crc)
  • Inhibitor of matrix metalloproteinase (timp)
  • Matrix metalloproteinase (mmp)
  • Microarray analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Gentner, B., Wein, A., Croner, R. S., Zeittraeger, I., Wirtz, R. M., Roedel, F., Dimmler, A., Dorlaque, L., Hohenberger, W., Hahn, E. G., & Brueckl, W. M. (2009). Differences In the Gene Expression Profile of Matrix Metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases. Anticancer Research, 29(1), 67-74.