Differences in the mechanism of induction of interferon-alpha by Herpes simplex virus and Herpes simplex virus-infected cells

M. R. Capobianchi, F. Malavasi, P. Di Marco, F. Dianzani

Research output: Contribution to journalArticlepeer-review

Abstract

The cellular source of IFN alpha after induction with Herpes simplex virus type-1 (HSV) and HSV-infected fibroblasts was investigated by using human peripheral blood mononuclear cell (PBMC) populations, purified according to conventional procedures, and which included T- and B-lymphocytes as well as monocytes. It appears that the cells responding to HSV virions are monocytes, whereas the PBMC population induced by HSV-infected cells is represented by B-lymphocytes. Furthermore, by using monoclonal antibody (MoAb) to HLA class I and class II products, it appears that different membrane structures are involved in the induction of IFN by HSV virions, as opposed to HSV-infected cells. In fact, most anti-HLA class II MoAbs inhibit IFN induction by HSV-infected cells, and not IFN induction by HSV virions.

Original languageEnglish
Pages (from-to)219-229
Number of pages11
JournalArchives of Virology
Volume103
Issue number3-4
DOIs
Publication statusPublished - Sep 1988

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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