Differences in the proportions of fluoroquinolone-resistant Gram-negative bacteria isolated from bacteraemic children with cancer in two Italian centres

Elio Castagnola, R. Haupt, A. Micozzi, I. Caviglia, A. M. Testi, F. Giona, S. Parodi, C. Girmenia

Research output: Contribution to journalArticle

Abstract

The proportion of ciprofloxacin-resistant Gram-negative bacteria isolated from the blood of children with cancer (not receiving prophylaxis) was 10% in a paediatric hospital (Genoa) where the use of quinolones was highly restricted, compared with 41% in a department of haematology (Rome) where leukaemic adults, who received fluoroquinolone prophylaxis, were also treated (p <0.0001). Moreover, simultaneous resistance to ciprofloxacin and ceftazidime, amikacin or imipenem-cilastatin was 11% in Genoa compared with 37% in Rome (p <0.001). Ciprofloxacin resistance was more frequent in children who shared an environment with adults who were receiving ciprofloxacin prophylaxis.

Original languageEnglish
Pages (from-to)505-507
Number of pages3
JournalClinical Microbiology and Infection
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Cancer patients
  • Children
  • Ciprofloxacin
  • Fluoroquinolone resistance
  • Prophylaxis
  • Resistance

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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