Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty

M. L. Finocchiaro, A. Buffon, J. F. Beltrame, A. Lupi, E. Conti, G. A. Lanza, D. Cianflone, F. Crea, A. Maseri

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Background: Previous studies reported a reduced coronary blood flow reserve, assessed by the intravenous administration of dipyridamole, in patients with angina and normal coronary arteries, and early after successful coronary angioplasty, which suggests the presence of small coronary vessel dysfunction. This study aimed to establish whether the mechanisms of small coronary vessel disease in these two groups of patients are similar. Methods: The effects of the intracoronary infusion of adenosine and dipyridamole (maximum dose 2.7 and 7.5mg/min, respectively) on coronary blood flow velocity were assessed in 11 patients with engine and normal coronary arteries (group A) and in 12 patients immediately after successful coronary angioplasty (group B) using a 0.018' Doppler wire. Results: Baseline coronary blood flow velocity was significantly higher in group B than group A (34 ± 14 versus 19 ± 8 cm/s; P = 0.001). In group A, coronary/blood flow velocity was higher during adenosine than dipyridamole infusion (74 ± 17 versus 58 ± 21 cm/s; P

Original languageEnglish
Pages (from-to)479-487
Number of pages9
JournalCoronary Artery Disease
Volume6
Issue number6
Publication statusPublished - 1995

Fingerprint

Dipyridamole
Angioplasty
Blood Flow Velocity
Coronary Vessels
Adenosine
Intravenous Administration
Coronary Disease

Keywords

  • adenosine
  • coronary angioplasty
  • coronary blood flow velocity
  • dipyridamole
  • Doppler flow wire
  • microvascular angina
  • syndrome X

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty. / Finocchiaro, M. L.; Buffon, A.; Beltrame, J. F.; Lupi, A.; Conti, E.; Lanza, G. A.; Cianflone, D.; Crea, F.; Maseri, A.

In: Coronary Artery Disease, Vol. 6, No. 6, 1995, p. 479-487.

Research output: Contribution to journal › Article

Finocchiaro, ML, Buffon, A, Beltrame, JF, Lupi, A, Conti, E, Lanza, GA, Cianflone, D, Crea, F & Maseri, A 1995, 'Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty', Coronary Artery Disease, vol. 6, no. 6, pp. 479-487.
Finocchiaro ML, Buffon A, Beltrame JF, Lupi A, Conti E, Lanza GA et al. Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty. Coronary Artery Disease. 1995;6(6):479-487.
Finocchiaro, M. L. ; Buffon, A. ; Beltrame, J. F. ; Lupi, A. ; Conti, E. ; Lanza, G. A. ; Cianflone, D. ; Crea, F. ; Maseri, A. / Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty. In: Coronary Artery Disease. 1995 ; Vol. 6, No. 6. pp. 479-487.
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AU - Finocchiaro, M. L.

AU - Buffon, A.

AU - Beltrame, J. F.

AU - Lupi, A.

AU - Conti, E.

AU - Lanza, G. A.

AU - Cianflone, D.

AU - Crea, F.

AU - Maseri, A.

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N2 - Background: Previous studies reported a reduced coronary blood flow reserve, assessed by the intravenous administration of dipyridamole, in patients with angina and normal coronary arteries, and early after successful coronary angioplasty, which suggests the presence of small coronary vessel dysfunction. This study aimed to establish whether the mechanisms of small coronary vessel disease in these two groups of patients are similar. Methods: The effects of the intracoronary infusion of adenosine and dipyridamole (maximum dose 2.7 and 7.5mg/min, respectively) on coronary blood flow velocity were assessed in 11 patients with engine and normal coronary arteries (group A) and in 12 patients immediately after successful coronary angioplasty (group B) using a 0.018' Doppler wire. Results: Baseline coronary blood flow velocity was significantly higher in group B than group A (34 ± 14 versus 19 ± 8 cm/s; P = 0.001). In group A, coronary/blood flow velocity was higher during adenosine than dipyridamole infusion (74 ± 17 versus 58 ± 21 cm/s; P

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