Differences in vasodilatory response to dipyridamole between patients with angina and normal coronary arteries and patients with successful coronary angioplasty

M. L. Finocchiaro, A. Buffon, J. F. Beltrame, A. Lupi, E. Conti, G. A. Lanza, D. Cianflone, F. Crea, A. Maseri

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Abstract

Background: Previous studies reported a reduced coronary blood flow reserve, assessed by the intravenous administration of dipyridamole, in patients with angina and normal coronary arteries, and early after successful coronary angioplasty, which suggests the presence of small coronary vessel dysfunction. This study aimed to establish whether the mechanisms of small coronary vessel disease in these two groups of patients are similar. Methods: The effects of the intracoronary infusion of adenosine and dipyridamole (maximum dose 2.7 and 7.5mg/min, respectively) on coronary blood flow velocity were assessed in 11 patients with engine and normal coronary arteries (group A) and in 12 patients immediately after successful coronary angioplasty (group B) using a 0.018' Doppler wire. Results: Baseline coronary blood flow velocity was significantly higher in group B than group A (34 ± 14 versus 19 ± 8 cm/s; P = 0.001). In group A, coronary/blood flow velocity was higher during adenosine than dipyridamole infusion (74 ± 17 versus 58 ± 21 cm/s; P

Original languageEnglish
Pages (from-to)479-487
Number of pages9
JournalCoronary Artery Disease
Volume6
Issue number6
Publication statusPublished - 1995

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Keywords

  • adenosine
  • coronary angioplasty
  • coronary blood flow velocity
  • dipyridamole
  • Doppler flow wire
  • microvascular angina
  • syndrome X

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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