Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Cristina Gussago; Beatrice Arosio; Martina Casati; Evelyn Ferri; Federica Gualandris; Enzo Tedone; Paola Nicolini; Paolo Dionigi Rossi; Carlo Abbate; Daniela Mari

doi:10.3233/JAD-131652

Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Cristina Gussago, Beatrice Arosio, Martina Casati, Evelyn Ferri, Federica Gualandris, Enzo Tedone, Paola Nicolini, Paolo Dionigi Rossi, Carlo Abbate, Daniela Mari

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A_2A receptor (A_2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A_2AR mRNA in VaD compared to AD subjects. These data suggest that A_2AR expression may help in the differential diagnosis between VaD and AD.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	40
Issue number	1
DOIs	https://doi.org/10.3233/JAD-131652
Publication status	Published - 2014

Keywords

Adenosine receptors
Alzheimer's disease
biomarker
vascular dementia

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology
Medicine(all)

Access to Document

10.3233/JAD-131652

Cite this

Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. / Gussago, Cristina; Arosio, Beatrice; Casati, Martina; Ferri, Evelyn; Gualandris, Federica; Tedone, Enzo; Nicolini, Paola; Rossi, Paolo Dionigi; Abbate, Carlo; Mari, Daniela.

In: Journal of Alzheimer's Disease, Vol. 40, No. 1, 2014, p. 45-49.

Research output: Contribution to journal › Article › peer-review

Gussago, Cristina ; Arosio, Beatrice ; Casati, Martina ; Ferri, Evelyn ; Gualandris, Federica ; Tedone, Enzo ; Nicolini, Paola ; Rossi, Paolo Dionigi ; Abbate, Carlo ; Mari, Daniela. / Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. In: Journal of Alzheimer's Disease. 2014 ; Vol. 40, No. 1. pp. 45-49.

@article{5d92129cad9b443eb8f5d0d4ebd09252,

title = "Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease",

abstract = "The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.",

keywords = "Adenosine receptors, Alzheimer's disease, biomarker, vascular dementia",

author = "Cristina Gussago and Beatrice Arosio and Martina Casati and Evelyn Ferri and Federica Gualandris and Enzo Tedone and Paola Nicolini and Rossi, {Paolo Dionigi} and Carlo Abbate and Daniela Mari",

year = "2014",

doi = "10.3233/JAD-131652",

language = "English",

volume = "40",

pages = "45--49",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

number = "1",

}

TY - JOUR

T1 - Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

AU - Gussago, Cristina

AU - Arosio, Beatrice

AU - Casati, Martina

AU - Ferri, Evelyn

AU - Gualandris, Federica

AU - Tedone, Enzo

AU - Nicolini, Paola

AU - Rossi, Paolo Dionigi

AU - Abbate, Carlo

AU - Mari, Daniela

PY - 2014

Y1 - 2014

N2 - The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.

AB - The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.

KW - Adenosine receptors

KW - Alzheimer's disease

KW - biomarker

KW - vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=84901319976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901319976&partnerID=8YFLogxK

U2 - 10.3233/JAD-131652

DO - 10.3233/JAD-131652

M3 - Article

C2 - 24321892

AN - SCOPUS:84901319976

VL - 40

SP - 45

EP - 49

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -

Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this