Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Cristina Gussago; Beatrice Arosio; Martina Casati; Evelyn Ferri; Federica Gualandris; Enzo Tedone; Paola Nicolini; Paolo Dionigi Rossi; Carlo Abbate; Daniela Mari

doi:10.3233/JAD-131652

Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Cristina Gussago, Beatrice Arosio, Martina Casati, Evelyn Ferri, Federica Gualandris, Enzo Tedone, Paola Nicolini, Paolo Dionigi Rossi, Carlo Abbate, Daniela Mari

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A_2A receptor (A_2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A_2AR mRNA in VaD compared to AD subjects. These data suggest that A_2AR expression may help in the differential diagnosis between VaD and AD.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Journal of Alzheimer's Disease
Volume	40
Issue number	1
DOIs	https://doi.org/10.3233/JAD-131652
Publication status	Published - 2014

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Keywords

Adenosine receptors
Alzheimer's disease
biomarker
vascular dementia

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology
Medicine(all)

Cite this

Gussago, C., Arosio, B., Casati, M., Ferri, E., Gualandris, F., Tedone, E., Nicolini, P., Rossi, P. D., Abbate, C., & Mari, D. (2014). Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. Journal of Alzheimer's Disease, 40(1), 45-49. https://doi.org/10.3233/JAD-131652

Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. / Gussago, Cristina; Arosio, Beatrice; Casati, Martina; Ferri, Evelyn; Gualandris, Federica; Tedone, Enzo; Nicolini, Paola; Rossi, Paolo Dionigi ; Abbate, Carlo; Mari, Daniela.

In: Journal of Alzheimer's Disease, Vol. 40, No. 1, 2014, p. 45-49.

Research output: Contribution to journal › Article

Gussago, Cristina ; Arosio, Beatrice ; Casati, Martina ; Ferri, Evelyn ; Gualandris, Federica ; Tedone, Enzo ; Nicolini, Paola ; Rossi, Paolo Dionigi ; Abbate, Carlo ; Mari, Daniela. / Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease. In: Journal of Alzheimer's Disease. 2014 ; Vol. 40, No. 1. pp. 45-49.

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10.3233/JAD-131652