Different adenosine A2A receptor expression in peripheral cells from elderly patients with vascular dementia and Alzheimer's disease

Cristina Gussago, Beatrice Arosio, Martina Casati, Evelyn Ferri, Federica Gualandris, Enzo Tedone, Paola Nicolini, Paolo Dionigi Rossi, Carlo Abbate, Daniela Mari

Research output: Contribution to journalArticle

Abstract

The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of Alzheimer's Disease
Volume40
Issue number1
DOIs
Publication statusPublished - 2014

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Keywords

  • Adenosine receptors
  • Alzheimer's disease
  • biomarker
  • vascular dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology
  • Medicine(all)

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