Abstract
We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).
Original language | English |
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Pages (from-to) | 733-736 |
Number of pages | 4 |
Journal | Biochemical Genetics |
Volume | 46 |
Issue number | 11-12 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- DNA
- Gender
- Linkage disequilibrium
- Polymorphism
- T-cell receptor
ASJC Scopus subject areas
- Biochemistry
- Genetics
- Molecular Biology
- Ecology, Evolution, Behavior and Systematics