Different allelic distribution of a single SNP between sexes in humans

P. Tripputi; D. Cigognini; S. Bianchi; L. Fedele

doi:10.1007/s10528-008-9188-0

Different allelic distribution of a single SNP between sexes in humans

P. Tripputi, D. Cigognini, S. Bianchi, L. Fedele

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ ² = 8.799, P = 0.012).

Original language	English
Pages (from-to)	733-736
Number of pages	4
Journal	Biochemical Genetics
Volume	46
Issue number	11-12
DOIs	https://doi.org/10.1007/s10528-008-9188-0
Publication status	Published - Dec 2008

Keywords

DNA
Gender
Linkage disequilibrium
Polymorphism
T-cell receptor

ASJC Scopus subject areas

Biochemistry
Genetics
Molecular Biology
Ecology, Evolution, Behavior and Systematics

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abstract = "We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).",

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AU - Tripputi, P.

AU - Cigognini, D.

AU - Bianchi, S.

AU - Fedele, L.

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AB - We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).

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KW - T-cell receptor

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Different allelic distribution of a single SNP between sexes in humans

Abstract

Keywords

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