Abstract
We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).
| Original language | English |
|---|---|
| Pages (from-to) | 733-736 |
| Number of pages | 4 |
| Journal | Biochemical Genetics |
| Volume | 46 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - Dec 2008 |
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Keywords
- DNA
- Gender
- Linkage disequilibrium
- Polymorphism
- T-cell receptor
ASJC Scopus subject areas
- Biochemistry
- Genetics
- Molecular Biology
- Ecology, Evolution, Behavior and Systematics
Cite this
Different allelic distribution of a single SNP between sexes in humans. / Tripputi, P.; Cigognini, D.; Bianchi, S.; Fedele, L.
In: Biochemical Genetics, Vol. 46, No. 11-12, 12.2008, p. 733-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Different allelic distribution of a single SNP between sexes in humans
AU - Tripputi, P.
AU - Cigognini, D.
AU - Bianchi, S.
AU - Fedele, L.
PY - 2008/12
Y1 - 2008/12
N2 - We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).
AB - We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).
KW - DNA
KW - Gender
KW - Linkage disequilibrium
KW - Polymorphism
KW - T-cell receptor
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U2 - 10.1007/s10528-008-9188-0
DO - 10.1007/s10528-008-9188-0
M3 - Article
VL - 46
SP - 733
EP - 736
JO - Biochemical Genetics
JF - Biochemical Genetics
SN - 0006-2928
IS - 11-12
ER -