Different allelic distribution of a single SNP between sexes in humans

P. Tripputi, D. Cigognini, S. Bianchi, L. Fedele

Research output: Contribution to journalArticle

Abstract

We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (χ 2 = 8.799, P = 0.012).

Original languageEnglish
Pages (from-to)733-736
Number of pages4
JournalBiochemical Genetics
Volume46
Issue number11-12
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Polymorphism
Single Nucleotide Polymorphism
gender
allele
polymorphism
T-Cell Antigen Receptor
Nucleotides
Gene Frequency
single nucleotide polymorphism
gene frequency
genotype
T-lymphocytes
Alleles
Genotype
genetic polymorphism
alleles
receptors
distribution
T34 toxin

Keywords

  • DNA
  • Gender
  • Linkage disequilibrium
  • Polymorphism
  • T-cell receptor

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Different allelic distribution of a single SNP between sexes in humans. / Tripputi, P.; Cigognini, D.; Bianchi, S.; Fedele, L.

In: Biochemical Genetics, Vol. 46, No. 11-12, 12.2008, p. 733-736.

Research output: Contribution to journalArticle

Tripputi, P. ; Cigognini, D. ; Bianchi, S. ; Fedele, L. / Different allelic distribution of a single SNP between sexes in humans. In: Biochemical Genetics. 2008 ; Vol. 46, No. 11-12. pp. 733-736.
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