Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease: A preliminary investigation

Davide Quaranta, Camillo Marra, Concettina Rossi, Guido Gainotti, Carlo Masullo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Apathy is one of the most common behavioral symptoms of dementia; it is one of the salient features of behavioral variant of frontotemporal dementia (bvFTD) but is also very frequent in Alzheimer's disease. This preliminary investigation was aimed at assessing the type of apathy-related symptoms in a population of bvFTD and AD subjects showing comparable apathy severity. Each patient underwent a comprehensive neuropsychological assessment; behavioral changes were investigated by the neuropsychiatric inventory (NPI), using the NPI-apathy subscale to detect apathetic symptoms. At univariate analysis, bvFTD subjects showed lack of initiation ( χ 2 = 4.602, p=0.032), reduced emotional output ( χ 2 =6.493, p=0.008), and reduced interest toward friends and family members ( 2 =4.898, p=0.027), more frequently than AD subjects. BvFTD displayed higher scores than AD on NPI total score (p=0.005) and on subscales assessing agitation (p=0.004), disinhibition (p=0.007) and sleep disturbances (p=0.025); conversely, AD subjects were more impaired on memory, constructional abilities, and attention. On multivariate logistic regression, reduced emotional output was highly predictive of bvFTD (OR=18.266; p=0.008). Our preliminary findings support the hypothesis that apathy is a complex phenomenon, whose clinical expression is conditioned by the site of anatomical damage. Furthermore, apathy profile may help in differentiating bvFTD from AD.

Original languageEnglish
Article number719250
JournalCurrent Gerontology and Geriatrics Research
Volume2012
DOIs
Publication statusPublished - 2012

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Apathy
Frontotemporal Dementia
Alzheimer Disease
Equipment and Supplies
Behavioral Symptoms
Aptitude
Dementia
Sleep
Logistic Models
Population

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease : A preliminary investigation. / Quaranta, Davide; Marra, Camillo; Rossi, Concettina; Gainotti, Guido; Masullo, Carlo.

In: Current Gerontology and Geriatrics Research, Vol. 2012, 719250, 2012.

Research output: Contribution to journalArticle

Quaranta, Davide ; Marra, Camillo ; Rossi, Concettina ; Gainotti, Guido ; Masullo, Carlo. / Different apathy profile in behavioral variant of frontotemporal dementia and Alzheimer's disease : A preliminary investigation. In: Current Gerontology and Geriatrics Research. 2012 ; Vol. 2012.
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