Different bacterial pathogens, different strategies, yet the aim is the same: Evasion of intestinal dendritic cell recognition

Sammy Bedoui, Andreas Kupz, Odilia L. Wijburg, Anna K. Walduck, Maria Rescigno, Richard A. Strugnell

Research output: Contribution to journalArticlepeer-review

Abstract

Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4+ T cells in the bacteria's favor.

Original languageEnglish
Pages (from-to)2237-2242
Number of pages6
JournalJournal of Immunology
Volume184
Issue number5
DOIs
Publication statusPublished - Mar 1 2010

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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