TY - JOUR
T1 - Different bacterial pathogens, different strategies, yet the aim is the same
T2 - Evasion of intestinal dendritic cell recognition
AU - Bedoui, Sammy
AU - Kupz, Andreas
AU - Wijburg, Odilia L.
AU - Walduck, Anna K.
AU - Rescigno, Maria
AU - Strugnell, Richard A.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4+ T cells in the bacteria's favor.
AB - Given the central role of intestinal dendritic cells (DCs) in the regulation of gut immune responses, it is not surprising that several bacterial pathogens have evolved strategies to prevent or bypass recognition by DCs. In this article, we will review recent findings on the interaction between intestinal DCs and prototypical bacterial pathogens, such as Salmonella, Yersinia, or Helicobacter. We will discuss the different approaches with which these pathogens seek to evade DC recognition and subsequent T cell activation. These diverse strategies span to include mounting irrelevant immune responses, inhibition of Ag presentation by DCs, and stretch as far as to manipulate the Th1/Th2 balance of CD4+ T cells in the bacteria's favor.
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U2 - 10.4049/jimmunol.0902871
DO - 10.4049/jimmunol.0902871
M3 - Article
C2 - 20164434
AN - SCOPUS:77951935481
VL - 184
SP - 2237
EP - 2242
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -