Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response

Gabriele Missale, Roberto Bertoni, Vincenzo Lamonaca, Antonietta Valli, Marco Massari, Cristina Mori, Maria Grazia Rumi, Michael Houghton, Franco Fiaccadori, Carlo Ferrari

Research output: Contribution to journalArticle

572 Citations (Scopus)

Abstract

The anti-viral T cell response is believed to play a central role in the pathogenesis of hepatitis C virus infection. Since chronic evolution occurs in > 50% of HCV infections, the sequential analysis of the T cell response from the early clinical stages of disease may contribute to define the features of the T cell response associated with recovery or chronic viral persistence. For this purpose, 21 subjects with acute hepatitis C virus infection were sequentially followed for an average time of 44 wk. Twelve patients normalized transaminase values that remained normal throughout the follow-up period; all but two cleared hepatitis C virus-RNA from serum. The remaining nine patients showed persistent viremia and elevated transaminases. Analysis of the peripheral blood T cell proliferative response to core, E1, E2, NS3, NS4, and NS5 recombinant antigens and synthetic peptides showed that responses to all hepatitis C virus antigens, except E1, were significantly more vigorous and more frequently detectable in patients who normalized transaminase levels than in those who did not. By sequential evaluation of the T cell response, a difference between the two groups of patients was already detectable at the very early stages of acute infection and then maintained throughout the follow-up period. The results suggest that the vigor of the T cell response during the early stages of infection may be a critical determinant of disease resolution and control of infection.

Original languageEnglish
Pages (from-to)706-714
Number of pages9
JournalJournal of Clinical Investigation
Volume98
Issue number3
Publication statusPublished - Aug 1 1996

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Virus Diseases
Hepacivirus
T-Lymphocytes
Transaminases
Hepatitis C Antigens
Infection
Synthetic Vaccines
Viremia
Infection Control
Blood Cells
Reference Values
RNA
Peptides
Serum

Keywords

  • antigens
  • peptides
  • proliferative response
  • T cells
  • viremia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. / Missale, Gabriele; Bertoni, Roberto; Lamonaca, Vincenzo; Valli, Antonietta; Massari, Marco; Mori, Cristina; Rumi, Maria Grazia; Houghton, Michael; Fiaccadori, Franco; Ferrari, Carlo.

In: Journal of Clinical Investigation, Vol. 98, No. 3, 01.08.1996, p. 706-714.

Research output: Contribution to journalArticle

Missale, G, Bertoni, R, Lamonaca, V, Valli, A, Massari, M, Mori, C, Rumi, MG, Houghton, M, Fiaccadori, F & Ferrari, C 1996, 'Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response', Journal of Clinical Investigation, vol. 98, no. 3, pp. 706-714.
Missale, Gabriele ; Bertoni, Roberto ; Lamonaca, Vincenzo ; Valli, Antonietta ; Massari, Marco ; Mori, Cristina ; Rumi, Maria Grazia ; Houghton, Michael ; Fiaccadori, Franco ; Ferrari, Carlo. / Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. In: Journal of Clinical Investigation. 1996 ; Vol. 98, No. 3. pp. 706-714.
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