Abstract
To test the role of necrosis, ischemia or both inbone marrow cells (BMC) mobilization in patients with cardiovascular disease. We studied three groups of patients: group 1, Iatrogenic Necrosis, with pure necrosis (28 patients undergoing transcatheter radiofrequency ablation); group 2, Ischemic Necrosis (30 patients with myocardial infarction); group 3, Pure Ischemia (24 patients with unstable angina). As control groups, we studied 27 patients with stable coronary artery disease (CAD), and 20 patients without CAD undergoing angiography for valvular diseases or cardiomiopathy. CD34 ? cells and cytokines were evaluated at: T 0 (baseline), 48 h and 5, 7, 10, 14 days thereafter. We observed a significant increase of CD34 + cells at T 3 and T 4 only in Iatrogenic Necrosis and Ischemic Necrosis group. The peak of mobilization was observed ten days after the necrotic event (2.8 ± 1.4 vs. 5.9 ± 1.9 in the group 1, P = 0.03; and 3 ± 1.5 vs. 5.6 ± 2 in the group 2, P = 0.04; respectively). We found a good correlation between CD34 + and vascular endothelial growth factor (VEGF) and stromal derived factor (SDF-1a) peak values (r = 0.77 and r = 0.63, respectively). At multivariable analysis, myocardial necrosis (OR 3.5, 95%CI 2.2-4.2, P
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Journal of Thrombosis and Thrombolysis |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2011 |
Fingerprint
Keywords
- Bone marrow cells
- CD34 + cells
- Cytokines
- Stromal derived factor
- Vascular endothelial factor
ASJC Scopus subject areas
- Hematology
- Cardiology and Cardiovascular Medicine
Cite this
Different clinical models of CD34 + cells mobilization in patients with cardiovascular disease. / Cangiano, Elisa; Cavazza, Caterina; Campo, Gianluca; Valgimigli, Marco; Francolini, Gloria; Malagutti, Patrizia; Pratola, Claudio; Ferrari, Roberto.
In: Journal of Thrombosis and Thrombolysis, Vol. 32, No. 1, 07.2011, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Different clinical models of CD34 + cells mobilization in patients with cardiovascular disease
AU - Cangiano, Elisa
AU - Cavazza, Caterina
AU - Campo, Gianluca
AU - Valgimigli, Marco
AU - Francolini, Gloria
AU - Malagutti, Patrizia
AU - Pratola, Claudio
AU - Ferrari, Roberto
PY - 2011/7
Y1 - 2011/7
N2 - To test the role of necrosis, ischemia or both inbone marrow cells (BMC) mobilization in patients with cardiovascular disease. We studied three groups of patients: group 1, Iatrogenic Necrosis, with pure necrosis (28 patients undergoing transcatheter radiofrequency ablation); group 2, Ischemic Necrosis (30 patients with myocardial infarction); group 3, Pure Ischemia (24 patients with unstable angina). As control groups, we studied 27 patients with stable coronary artery disease (CAD), and 20 patients without CAD undergoing angiography for valvular diseases or cardiomiopathy. CD34 ? cells and cytokines were evaluated at: T 0 (baseline), 48 h and 5, 7, 10, 14 days thereafter. We observed a significant increase of CD34 + cells at T 3 and T 4 only in Iatrogenic Necrosis and Ischemic Necrosis group. The peak of mobilization was observed ten days after the necrotic event (2.8 ± 1.4 vs. 5.9 ± 1.9 in the group 1, P = 0.03; and 3 ± 1.5 vs. 5.6 ± 2 in the group 2, P = 0.04; respectively). We found a good correlation between CD34 + and vascular endothelial growth factor (VEGF) and stromal derived factor (SDF-1a) peak values (r = 0.77 and r = 0.63, respectively). At multivariable analysis, myocardial necrosis (OR 3.5, 95%CI 2.2-4.2, P
AB - To test the role of necrosis, ischemia or both inbone marrow cells (BMC) mobilization in patients with cardiovascular disease. We studied three groups of patients: group 1, Iatrogenic Necrosis, with pure necrosis (28 patients undergoing transcatheter radiofrequency ablation); group 2, Ischemic Necrosis (30 patients with myocardial infarction); group 3, Pure Ischemia (24 patients with unstable angina). As control groups, we studied 27 patients with stable coronary artery disease (CAD), and 20 patients without CAD undergoing angiography for valvular diseases or cardiomiopathy. CD34 ? cells and cytokines were evaluated at: T 0 (baseline), 48 h and 5, 7, 10, 14 days thereafter. We observed a significant increase of CD34 + cells at T 3 and T 4 only in Iatrogenic Necrosis and Ischemic Necrosis group. The peak of mobilization was observed ten days after the necrotic event (2.8 ± 1.4 vs. 5.9 ± 1.9 in the group 1, P = 0.03; and 3 ± 1.5 vs. 5.6 ± 2 in the group 2, P = 0.04; respectively). We found a good correlation between CD34 + and vascular endothelial growth factor (VEGF) and stromal derived factor (SDF-1a) peak values (r = 0.77 and r = 0.63, respectively). At multivariable analysis, myocardial necrosis (OR 3.5, 95%CI 2.2-4.2, P
KW - Bone marrow cells
KW - CD34 + cells
KW - Cytokines
KW - Stromal derived factor
KW - Vascular endothelial factor
UR - http://www.scopus.com/inward/record.url?scp=80052471043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052471043&partnerID=8YFLogxK
U2 - 10.1007/s11239-010-0543-8
DO - 10.1007/s11239-010-0543-8
M3 - Article
C2 - 21197559
AN - SCOPUS:80052471043
VL - 32
SP - 1
EP - 8
JO - Journal of Thrombosis and Thrombolysis
JF - Journal of Thrombosis and Thrombolysis
SN - 0929-5305
IS - 1
ER -