Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction

S. Ghio, M. Guazzi, A.B. Scardovi, C. Klersy, F. Clemenza, E. Carluccio, P.L. Temporelli, A. Rossi, P. Faggiano, E. Traversi, O. Vriz, F.L. Dini, on behalf of all investigators

Research output: Contribution to journalArticle

Abstract

Aims: To evaluate whether the clinical and echocardiographic correlates and the prognostic significance of right ventricular (RV) dysfunction are different in heart failure patients with reduced (HFrEF), mid-range (HFmrEF), or preserved (HFpEF) left ventricular ejection fraction. Methods and results: The study included 1663 patients with heart failure caused by ischaemic or hypertensive heart disease or by idiopathic cardiomyopathy. Left ventricular ejection fraction was 40 mmHg was by far the strongest correlate of a reduced TAPSE in HFpEF and HFmrEF patients (interaction analysis, P = 0.0011). TAPSE/PASP proved to be a powerful predictor of prognosis in all patients. Conclusions: The correlates of RV dysfunction differ in HFrEF compared with HFpEF and HFmrEF patients. Regardless of the extent of LV dysfunction, the TAPSE/PASP ratio is a powerful independent predictor of prognosis in all heart failure patients. © 2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology
Original languageEnglish
Pages (from-to)873-879
Number of pages7
JournalEuropean Journal of Heart Failure
Volume19
Issue number7
DOIs
Publication statusPublished - 2017

Keywords

  • Echocardiography
  • Heart failure
  • Pulmonary hypertension
  • Right ventricle
  • adult
  • aged
  • Article
  • cardiomyopathy
  • cause of death
  • cohort analysis
  • controlled study
  • diagnostic test accuracy study
  • echocardiography
  • female
  • heart failure with preserved ejection fraction
  • heart failure with reduced ejection fraction
  • heart left ventricle ejection fraction
  • heart rate
  • heart right ventricle failure
  • heart right ventricle function
  • human
  • hypertension
  • ischemic heart disease
  • major clinical study
  • male
  • priority journal
  • prognosis
  • pulmonary artery
  • receiver operating characteristic
  • retrospective study
  • sinus rhythm
  • survival analysis
  • systolic blood pressure

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