Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells

J. T. Wroblewski, F. Nicoletti, E. Costa

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebellar granule cells in primary culture express receptors for excitatory amino acids. The activation of these receptors results in an increased uptake of Ca2+, however, the effects are different depending on the agonists used. Aspartate, NMDA and ibotenate are active only in depolarized conditions, whereas kainate and glutamate activate Ca2+ uptake independently from depolarization. The results indicate the presence of two receptor types: kainate recognition site coupled with voltage-independent Ca2+ channels and NMDA recognition site coupled with voltage-dependent Ca2+ channels.

Original languageEnglish
Pages (from-to)919-921
Number of pages3
JournalNeuropharmacology
Volume24
Issue number9
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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