Different cytokine production and effector/memory dynamics of αβ+ or γδ+ T-cell subsets in the peripheral blood of patients with active pulmonary tuberculosis

C. Gioia, C. Agrati, D. Goletti, D. Vincenti, S. Carrara, M. Amicosante, M. Casarini, S. Giosue, G. Puglisi, A. Rossi, V. Colizzi, L. P. Pucillo, F. Poccia

Research output: Contribution to journalArticlepeer-review

Abstract

Immunity to M.tuberculosis (MTB) infection consists of interactions between various T-cell subsets that control the infection and prevent further reactivation. We analysed the effector/memory T-cell dynamics and cytokines production in the peripheral blood of patients with pulmonary tuberculosis (TB). We observed that the frequency of CD4+ T-cell effectors was significantly increased during active TB, confirming a major role of this T-cell subset in TB immunity. Pre-terminally differentiated CD8+ T-lymphocytes were increased in the peripheral blood as well. In contrast, we observed a reduced number of effector mycobacteria-reactive γδ + T-lymphocytes with a specific defects in reacting to mycobacterial nonpeptidic antigens, suggesting that this innate response is rapidly lost during TB infection. Nevertheless, the frequency of γδ+ T-cells effectors in TB patients was higher than the αβ+ T-cell response to peptide from MTB-ESAT-6 protein and quantitatively similar to PPD reactivity. Thus, αβ+ and γδ+ T-cell differentiation and function are differently triggered by active TB infection.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume16
Issue number3
Publication statusPublished - Sep 2003

Keywords

  • IFN-γ
  • M.tuberculosis
  • Mycobacterial antigens

ASJC Scopus subject areas

  • Pharmacology

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