Different EEG frequency band synchronization during nocturnal frontal lobe seizures

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: In this article we describe the course of synchronization between different EEG channels during nocturnal seizures in one patient with nocturnal frontal lobe epilepsy (NFLE). Methods: The functional interactions between the different EEG channels during the nocturnal seizures were analyzed by means of the so-called synchronization likelihood (SL). SL is a measure of the dynamical interdependencies between a time series (EEG channel) and one or more other time series. In contrast to coherence, SL measures linear as well as non-linear interdependencies and it can do so as a function of time, making it suitable for non-stationary time series. Results: The main result of our single-patient study is the demonstration of a significant hyper- synchronization during NFLE seizures in the 8-12 Hz band which seems to be stopped by an increase in synchronization in the 0.5-4 Hz band, towards the end of each ictal episode. Conclusions: We suggest that a self-inhibiting complex mechanism might be responsible for the termination of ictal episodes which might take place at the level of the cortical layers and might involve mainly pyramidal neurons. Significance: This study shows that advanced EEG analysis methods can help the current understanding of ictal manifestations of NFLE.

Original languageEnglish
Pages (from-to)1202-1211
Number of pages10
JournalClinical Neurophysiology
Volume115
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Epilepsy
  • Frequency band synchronization
  • Nocturnal frontal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems

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