Different effect of percutaneous and surgical coronary revascularization on cardiac autonomic function and inflammation in patients with stable angina

Pasquale Santangeli, Gregory Angelo Sgueglia, Alfonso Sestito, Priscilla Lamendola, Luca Mariani, Fabio Infusino, Giampaolo Niccoli, Filippo Crea, Gaetano Antonio Lanza

Research output: Contribution to journalArticle

Abstract

We assessed heart rate variability (HRV) and high-sensitivity C-reactive protein (CRP) serum levels in 77 patients with chronic stable angina (CSA), 47 of whom had obstructive coronary artery disease (CAD) and 30 normal or near-normal coronary arteries (NCA). The effect of percutaneous coronary interventions (PCI) and bypass surgery (CABG) on HRV and CRP was assessed in 36 patients (18 PCI, 18 CABG) 6 months after the intervention. A significant inverse correlation was found between CRP levels and HRV variables in CAD patients (best r value = - 0.31, p = 0.036 for very low frequency amplitude), but not in NCA patients. At follow-up, however, no significant correlation was found between CRP and HRV in PCI and CABG treated patients. Thus, while confirming the presence of a relation between cardiac autonomic dysfunction and inflammation in CAD patients, our data show that the association is lost after revascularization procedures.

Original languageEnglish
Pages (from-to)269-270
Number of pages2
JournalInternational Journal of Cardiology
Volume127
Issue number2
DOIs
Publication statusPublished - Jul 4 2008

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Keywords

  • C-reactive protein
  • Coronary artery bypass
  • Heart rate variability
  • Percutaneous coronary intervention
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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