Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: A six-month, randomized clinical trial

Arrigo F G Cicero, Giuseppe Derosa, Marco Manca, Marilisa Bove, Claudio Borghi, Antonio V. Gaddi

Research output: Contribution to journalArticle

Abstract

In the setting of a six-month, open-label clinical trial, 141 consecutively enrolled, hypertensive, overweight patients were randomized to the oral ingestion of psyllium powder or guar gum 3.5 gr t.i.d., to be taken 20 min before the main two meals, or to standard diet. Both fibers improved significantly BMI, FPG, FPI, HOMA Index, HbA1c, LDL-C, and ApoB. Psyllium supplementation only exerted a significant improvement in plasma TG concentration, in SBP and DBP. In our study, six-month supplementation with psyllium fiber, but not with guar fiber nor standard diet, appears to significantly reduce both SBP and DBP in hypertensive overweight subjects.

Original languageEnglish
Pages (from-to)383-394
Number of pages12
JournalClinical and Experimental Hypertension
Volume29
Issue number6
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Hypercholesterolemia
  • Hyperglycemia
  • Hypertension
  • Overweight
  • Soluble fibers

ASJC Scopus subject areas

  • Internal Medicine

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