Different effects of acute and chronic stress on two dopamine-mediated behaviors in the mouse

Simona Cabib, Eliane Kempf, Carmen Schleef, Andrea Mele, Stefano Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

After two hours of immobilization stress, C57BL/6 mice presented a significant reduction of spontaneous locomotion and a slight reduction of spontaneous climbing. The effect of stress on locomotor activity disappeared after ten daily sessions of immobilization while this chronic treatment increased the effect of stress on spontaneous climbing. Twenty-four hr after the last stressful experience the mice showed an increase of spontaneous locomotion and a decrease of spontaneous climbing in comparison with unstressed mice. Following a single exposure to immobilization stress, an increase of DOPAC/DA and HVA/DA ratios was found in the striatum and in the nucleus accumbens. These effects were still evident following repeated exposure to this stressor but disappeared 24 hr after the last of ten daily stressful experiences. Finally, chronically stressed mice, tested 24 hr after the last stressful experience, showed an increased sensitivity to the inhibitory effects of low doses of apomorphine on climbing behavior and a decreased sensitivity to the inhibitory effects of the same doses of the dopamine agonist on locomotion. These results are discussed in terms of altered sensitivity of different populations of dopamine receptors following chronic stress.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalPhysiology and Behavior
Volume43
Issue number2
DOIs
Publication statusPublished - 1988

Keywords

  • Apomorphine
  • Climbing
  • Dopamine
  • Locomotion
  • Mice
  • Sensitization
  • Stress
  • Tolerance

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Different effects of acute and chronic stress on two dopamine-mediated behaviors in the mouse'. Together they form a unique fingerprint.

Cite this