Different effects of apomorphine on locomotor activity in C57BL/6 and DBA/2 mice

Mario Sansone, Martine Ammassari-Teule, Paolo Renzi, Alberto Oliverio

Research output: Contribution to journalArticle

Abstract

The effects of apomorphine on spontaneous locomotor activity have been studied in two inbred strains of mice, the C57BL/6 and the DBA/2. In C57 mice low doses of apomorphine reduced motor activity, while higher doses produced hypermotility. In DBA mice the drug always depressed locomotor activity. The results have also been discussed in relation to the different sensitivities to morphine exhibited by the same two strains of mice.

Original languageEnglish
Pages (from-to)741-743
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume14
Issue number5
DOIs
Publication statusPublished - 1981

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Keywords

  • Apomorphine
  • Locomotor activity
  • Mice

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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