Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa

Antonello E. Rigamonti, Alessandro Sartorio, Pasquale Scognamiglio, Silvia Bini, Alessio M. Monteleone, Daniele Mastromo, Nicoletta Marazzi, Silvano G. Cella, Palmiero Monteleone

Research output: Contribution to journalArticle

Abstract

Objective: Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, affecting the secretion of both CCK and PYY. To further characterise the physiology of these peptides in BN, we aimed to investigate the effects of cholestyramine (12 g, per os) or placebo administered with a high-fat meal on CCK and PYY secretions in bulimic versus healthy women. Results: Postprandial CCK levels significantly increased in both healthy and bulimic women after placebo + the high-fat meal, without any significant difference between the two groups. Cholestyramine administration significantly increased postprandial CCK responses in both healthy and bulimic women; however, significantly lower CCK levels were observed in BN. Postprandial PYY levels significantly increased after placebo administration in healthy women after the high-fat meal, whereas no significant changes were found in bulimic women. Cholestyramine, administered with the high-fat meal, significantly reduced postprandial PYY response in healthy women, but not in bulimic women. Finally, there was a negative correlation of the area under the curve with respect to the increase of PYY (after placebo administration) with binge frequency in the bulimic women. Conclusion: In BN an altered postprandial secretion of CCK may be evidenced when cholestyramine is combined with a high-fat meal. Instead, the postprandial secretion of PYY is significantly blunted and not affected by cholestyramine administration.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalNeuropsychobiology
Volume70
Issue number4
DOIs
Publication statusPublished - Mar 19 2014

Fingerprint

Peptide YY
Cholestyramine Resin
Bulimia Nervosa
Cholecystokinin
Meals
Fats
Placebos
Peptides
Bile Acids and Salts
Area Under Curve
Anions
Digestion
Lipids
Food

Keywords

  • Bulimia nervosa
  • Cholecystokinin
  • Cholestyramine
  • Peptide YY

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa. / Rigamonti, Antonello E.; Sartorio, Alessandro; Scognamiglio, Pasquale; Bini, Silvia; Monteleone, Alessio M.; Mastromo, Daniele; Marazzi, Nicoletta; Cella, Silvano G.; Monteleone, Palmiero.

In: Neuropsychobiology, Vol. 70, No. 4, 19.03.2014, p. 228-234.

Research output: Contribution to journalArticle

Rigamonti, AE, Sartorio, A, Scognamiglio, P, Bini, S, Monteleone, AM, Mastromo, D, Marazzi, N, Cella, SG & Monteleone, P 2014, 'Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa', Neuropsychobiology, vol. 70, no. 4, pp. 228-234. https://doi.org/10.1159/000368160
Rigamonti, Antonello E. ; Sartorio, Alessandro ; Scognamiglio, Pasquale ; Bini, Silvia ; Monteleone, Alessio M. ; Mastromo, Daniele ; Marazzi, Nicoletta ; Cella, Silvano G. ; Monteleone, Palmiero. / Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa. In: Neuropsychobiology. 2014 ; Vol. 70, No. 4. pp. 228-234.
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abstract = "Objective: Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, affecting the secretion of both CCK and PYY. To further characterise the physiology of these peptides in BN, we aimed to investigate the effects of cholestyramine (12 g, per os) or placebo administered with a high-fat meal on CCK and PYY secretions in bulimic versus healthy women. Results: Postprandial CCK levels significantly increased in both healthy and bulimic women after placebo + the high-fat meal, without any significant difference between the two groups. Cholestyramine administration significantly increased postprandial CCK responses in both healthy and bulimic women; however, significantly lower CCK levels were observed in BN. Postprandial PYY levels significantly increased after placebo administration in healthy women after the high-fat meal, whereas no significant changes were found in bulimic women. Cholestyramine, administered with the high-fat meal, significantly reduced postprandial PYY response in healthy women, but not in bulimic women. Finally, there was a negative correlation of the area under the curve with respect to the increase of PYY (after placebo administration) with binge frequency in the bulimic women. Conclusion: In BN an altered postprandial secretion of CCK may be evidenced when cholestyramine is combined with a high-fat meal. Instead, the postprandial secretion of PYY is significantly blunted and not affected by cholestyramine administration.",
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T1 - Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa

AU - Rigamonti, Antonello E.

AU - Sartorio, Alessandro

AU - Scognamiglio, Pasquale

AU - Bini, Silvia

AU - Monteleone, Alessio M.

AU - Mastromo, Daniele

AU - Marazzi, Nicoletta

AU - Cella, Silvano G.

AU - Monteleone, Palmiero

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N2 - Objective: Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, affecting the secretion of both CCK and PYY. To further characterise the physiology of these peptides in BN, we aimed to investigate the effects of cholestyramine (12 g, per os) or placebo administered with a high-fat meal on CCK and PYY secretions in bulimic versus healthy women. Results: Postprandial CCK levels significantly increased in both healthy and bulimic women after placebo + the high-fat meal, without any significant difference between the two groups. Cholestyramine administration significantly increased postprandial CCK responses in both healthy and bulimic women; however, significantly lower CCK levels were observed in BN. Postprandial PYY levels significantly increased after placebo administration in healthy women after the high-fat meal, whereas no significant changes were found in bulimic women. Cholestyramine, administered with the high-fat meal, significantly reduced postprandial PYY response in healthy women, but not in bulimic women. Finally, there was a negative correlation of the area under the curve with respect to the increase of PYY (after placebo administration) with binge frequency in the bulimic women. Conclusion: In BN an altered postprandial secretion of CCK may be evidenced when cholestyramine is combined with a high-fat meal. Instead, the postprandial secretion of PYY is significantly blunted and not affected by cholestyramine administration.

AB - Objective: Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, affecting the secretion of both CCK and PYY. To further characterise the physiology of these peptides in BN, we aimed to investigate the effects of cholestyramine (12 g, per os) or placebo administered with a high-fat meal on CCK and PYY secretions in bulimic versus healthy women. Results: Postprandial CCK levels significantly increased in both healthy and bulimic women after placebo + the high-fat meal, without any significant difference between the two groups. Cholestyramine administration significantly increased postprandial CCK responses in both healthy and bulimic women; however, significantly lower CCK levels were observed in BN. Postprandial PYY levels significantly increased after placebo administration in healthy women after the high-fat meal, whereas no significant changes were found in bulimic women. Cholestyramine, administered with the high-fat meal, significantly reduced postprandial PYY response in healthy women, but not in bulimic women. Finally, there was a negative correlation of the area under the curve with respect to the increase of PYY (after placebo administration) with binge frequency in the bulimic women. Conclusion: In BN an altered postprandial secretion of CCK may be evidenced when cholestyramine is combined with a high-fat meal. Instead, the postprandial secretion of PYY is significantly blunted and not affected by cholestyramine administration.

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